Scientist

Insight Global; Spring House (PA); On-site; USD 110,000 - 140,000; Full time

Job summary

Insight Global, on the Cell Therapy Platform & Discovery team, seeks a Scientist, Cell Therapy Vector Biology to help drive discovery and development of novel Cell and Gene Therapies. The role focuses on engineered viral vectors for ex vivo and in vivo delivery to T cells to treat cancer.

You will design downstream purification processes for LVV, operate chromatography systems, and collaborate across teams to deliver purified vector lots for preclinical studies.

Qualifications

• BS or MS in Biological/chemical engineering or related field with 2+ years of experience.
• Experience with viral vector downstream processing and column chromatography (AKTA).
• Familiarity with analytical techniques for lentiviral vectors.
• Strong collaboration and data-record keeping skills.

Responsibilities

• Design and optimize LVV downstream purification to improve yield and purity.
• Operate chromatography and filtration systems for virus purification.
• Collaborate with cross-functional teams to support preclinical studies.
• Maintain detailed records for traceability and data integrity.

Skills

Downstream processing

Chromatography

Vector biology

Data management

Education

BS/MS in Biological/ Chemical Engineering or related

Virology

Tools

AKTA chromatography

TFF

Depth filtration

Job description

Join the Cell Therapy Platform & Discovery team as a Scientist, Cell Therapy Vector Biology, where you will help drive the discovery and development of novel Cell and Gene Therapies. This role provides the opportunity to make a meaningful impact by advancing cutting-edge treatments for diseases with significant unmet medical needs. We are investigating the use of engineered viral vectors for ex vivo and in vivo gene delivery to T cells to treat cancer. We are seeking a highly motivated downstream process scientist to develop and implement vector purification strategies to enable preclinical studies. Do you have industry experience with downstream viral vector process development and the ability to thrive in a cross-functional team? Come join us in our mission to build the next generation of Cell & Gene Therapies for Oncology.

Primary responsibilities:

• Design, optimize, and execute downstream purification processes to improve yield, purity, and stability of lentiviral vectors (LVV)
• Independently operate and maintain chromatography and filtration systems (e.g., TFF, depth filtration) for virus purification
• Collaborate with stakeholders to ensure timely delivery of purified, quality-controlled vector lots to support preclinical studies
• Maintain detailed records for vector productions and process development experiments to ensure traceability and data integrity
• Contribute to a collaborative, creative, and rigorous culture of scientific discovery

Qualifications:

• BS or MS in Biological Engineering, Chemical Engineering, Virology, Biology, or related field with 2+ years of related experience is required. Industry experience is preferred.
• Experience with viral vector downstream processing methods, including column chromatography (Akta), is required; expertise in LVV purification is preferred
• Familiarity with analytical techniques for lentiviral vectors is preferred
• Strong critical, scientific, and strategic thinking skills are required
• Strong organizational skills, with the ability to independently manage multiple projects in parallel, are required
• Demonstrated ability to work collaboratively in cross-functional teams is required