Scientist III

Katalyst Healthcares & Life Sciences; Worcester (MA); On-site; USD 80,000 - 120,000; Full time

Job summary

A leading company in medical research is looking for a highly motivated scientist to lead gene therapy projects involving lentiviral delivery platforms. This role requires a Ph.D. with extensive experience in lentiviral vectors and offers the opportunity to collaborate with cross-functional teams. Candidates should have a proven track record in vector design and production, along with strong communication skills. This is a full-time opportunity located in Worcester, MA, focused on advancing innovative therapies.

Qualifications

• Ph.D. with 5+ years of experience in lentiviral vector-based gene therapy.
• Experience in managing CROs for lentiviral production.
• Detail oriented with a passion to deliver quality results.

Responsibilities

• Collaborate with teams to advance lentiviral vectors.
• Design and engineer lentiviral vectors managing production.
• Establish analytical and cell-based screening assays.

Skills

Lentiviral vector design

Project management

Analytical methods

Collaboration

Communication skills

Education

Ph.D. in biology or relevant field

Job description

• Katalyst Healthcares & Life Sciences is hiring entry level candidates for several positions for contract research in Clinical trials of drugs, biologics and medical devices.
• We have a few immediate job opportunities available in Drug Safety and Pharmacovigilance and Clinical Research field. We work with University hospitals, pharmaceutical companies and recruiting partners.

Job Description

Job Description:
The Biotherapeutics and Genetic Medicine Group is seeking a highly motivated scientist for initiating the lentiviral delivery platform for gene therapy in a newly established Genetic Medicine team. The candidate will work collaboratively with cross-functional and therapeutic area teams to advance company's lentiviral gene therapy pipeline. The ideal candidate will have strong expertise and experience in lentivirus vector engineering, production, analytics and in vitro screening, as well as experience in managing CROs for lentiviral production.Responsibilities:

• Collaborate with cross-functional and therapeutic area teams to advance Client lentiviral vectors into pipeline.
• Design and engineer lentiviral vectors and manage lentiviral production by leveraging internal and CRO resources.
• Help build and establish analytical and cell-based screening assays (e.g., p24, VCN, SupT1 titration, ELISA, qPCR, ddPCR, WES, FACS, and endotoxin assay).
• Maintain a comprehensive Electronic Lab Notebook documenting experiments.
• Maintain a high level of productivity in the team with clear daily, detailed, and accurate documentation of experiments.
• Author technical reports and protocols.
• Understand and enforce company culture, teamwork, safety, appropriate handling of materials in an BSL2 environment.
• Perform all activities in compliance with applicable regulations, client's policies and guidelines.
• Bring a "can do " spirit to work and deliver on other responsibilities as assigned.

Requirements:

• Ph.D. in biology or a relevant field with 5+ years of experience in lentiviral vector-based gene therapy in addition to post-doctoral experience; or MS with at least 10 years of relevant experience; industrial experience highly desired
• Strong expertise and experience in lentiviral vector design, engineering and production.
• Experience in managing CROs for lentiviral production.
• Experience in analytical and screening methods for characterization of lentiviral vector products Experience in CAR-T cell therapy.
• Experience in in vivo lentiviral targeted delivery is a plus.
• Ability to work effectively in a highly collaborative and dynamic environment.
• Excellent verbal and written communication skills.
• Excellent organization and collaborative skills.
• Detail oriented with a passion to deliver quality results.

Additional Information

All your information will be kept confidential according to EEO guidelines.