Scientist II, Downstream Viral Vector Process Development

GeneFab; Alameda (CA); On-site; USD 130,000 - 150,000; Full time

Job summary

GeneFab is looking for an experienced Downstream Process Development Scientist/Lead. This role focuses on viral vector purification for in-vivo gene therapy, emphasizing process optimization and cross-functional leadership.

Qualified candidates hold a Ph.D. or Master’s degree with significant industry experience in downstream process development, particularly for AAV and lentiviral vectors. The position offers a competitive salary of $130,000 - $150,000 per year.

Qualifications

• Minimum of 3 years (Ph.D.) or 5 years (Master’s) relevant industry experience.
• Proven expertise in downstream process development for AAV and lentiviral vectors.
• Hands-on experience with chromatography and filtration techniques.

Responsibilities

• Design and optimize downstream processes for viral vector purification.
• Execute experimental plans and improve process efficiency.
• Collaborate with cross-functional teams for integration.

Skills

Downstream process development

Chromatography

Filtration

Strong analytical skills

Communication skills

Problem-solving skills

Education

Ph.D. in Chemical Engineering or related field

Master's degree in relevant field with 5 years of experience

Tools

TFF

Job description

GeneFab is seeking an experienced Downstream Process Development Scientist/Lead focused on viral vector purification (AAV and Lentiviral) for in‑vivo gene therapy. It is a technical, project‑based role within a CRDMO environment that balances hands‑on process optimization with cross‑functional leadership and client‑facing responsibilities.

Responsibilities

• Design, optimize, and scale‑up downstream processes for the purification of viral vectors, with a focus on in‑vivo gene therapy products and lentiviral vectors.
• Execute experimental plans, analyze data, and provide insightful recommendations to improve process efficiency, yield, and product quality.
• Collaborate with cross‑functional teams, including Upstream Process Development, Analytical Development, and Manufacturing, to ensure seamless integration of processes.
• Troubleshoot and resolve technical challenges in downstream processes, ensuring robust and scalable solutions.
• Present internally and to client with project status updates.
• Stay abreast of industry trends, emerging technologies, and regulatory guidelines to contribute to the continuous improvement of processes and compliance.
• Provide direction and leadership to development associates as the team expands.

Qualifications

• Ph.D. or Master’s degree in Chemical Engineering, Biochemical Engineering, Biotechnology, or related field with a minimum of 3 years (Ph.D.) or 5 years (Master’s) of relevant industry experience.
• Proven expertise in downstream process development for viral vectors, with a focus on AAV and lentiviral vectors.
• Hands‑on experience with chromatography, filtration, TFF and other downstream processing techniques.
• Strong analytical and problem‑solving skills, with the ability to interpret complex data sets.
• Excellent communication skills and the ability to work collaboratively in a team environment.
• Knowledge of regulatory requirements and quality standards related to biopharmaceutical manufacturing.
• Experience with formulation science preferred.

$130,000 - $150,000 a year

About GeneFab

GeneFab is a contract manufacturing and synthetic biology biofoundry focused on cell and gene therapies. GeneFab was formed in 2023 with a vision to combine industry‑leading expertise in synthetic biology with advanced cGMP capabilities in order to accelerate the development and commercialization of genetic medicines. GeneFab offers its customers an extensive technology platform and know‑how that spans early stage product design, technical development, and cGMP compliant production. GeneFab’s technology platform includes bioinformatic‑guided discovery of cell type promoters, directed evolution of small molecule‑regulated gene switches, and the engineering of highly sensitive kill switches for enhanced safety and control of cellular therapies.

We are committed to an inclusive and diverse GeneFab. We believe that different perspectives lead to better ideas, and better ideas allow us to better understand the needs and interests of our diverse GeneFab team. We welcome people of different backgrounds, experiences, abilities, and perspectives and are an equal opportunity employer.