Research Scientist, RNA Therapeutics for Liver Disease

Deep Genomics; Cambridge (MA); On-site; USD 135,000 - 165,000; Full time

Job summary

Deep Genomics in Cambridge, MA, seeks a Research Scientist to design and run cell-based studies assessing oligo-based therapies including ADAR-mediated RNA editing and siRNA for liver disease. You will build liver disease models and connect editing data to biological outcomes.

As an individual contributor, you will collaborate with teams in Cambridge and Toronto, applying advanced assays, imaging, and biomarker readouts to inform therapeutic decisions and advance the program.

Qualifications

• PhD in cell biology or related field with 0–3+ years postdoc, or Masters/BS with 6+ years biotech experience.
• Deep understanding of liver disease models and functional assays.
• Experience with RNA therapeutics and experimental controls.
• Experience with ELISA, MSD, Western blot, or Jess and high-content imaging.
• Ability to integrate phenotypic data with molecular analyses with computational partners.
• Experience with laboratory automation and rigorous record-keeping.

Responsibilities

• Design and run functional assays in liver disease models.
• Evaluate ADAR RNA editing and siRNA candidates and dose response.
• Develop endpoints for assays and high-content imaging workflows.
• Interpret results with computational colleagues.
• Use automation to improve throughput and data quality.
• Collaborate with teams in Cambridge and Toronto.
• Communicate findings to leadership and peers.

Skills

Cell biology

Molecular biology

Biochemistry

Genetics

RNA therapeutics

High-content imaging

Data analysis

Lab automation

Experimental design

Cross-site collaboration

Education

PhD in a relevant field

Masters/BS with 6+ years biotech exp

Tools

ELISA

MSD

Western blot

Jess

RNAseq

Next-gen sequencing

Organoids

Primary cells

Job description

Deep Genomics in Cambridge, MA, seeks a Research Scientist to design and run cell-based studies assessing oligo-based therapies including ADAR-mediated RNA editing and siRNA for liver disease. You will build liver disease models and connect editing data to biological outcomes.

As an individual contributor, you will collaborate with teams in Cambridge and Toronto, applying advanced assays, imaging, and biomarker readouts to inform therapeutic decisions and advance the program.