Research Scientist, In Vitro ADME

JobDiva, Inc.; Wilmington (DE); On-site; USD 90,000 - 130,000; Full time

Job summary

Kaztronix is seeking a Research Scientist In Vitro ADME to oversee scheduling, conduct, analysis, archiving, and reporting of weekly in vitro screening assays including metabolic intrinsic clearance, CYP450 inhibition, and reaction phenotyping studies.

The role involves building LC-MS/MS methods for high-throughput ADME assays, data analysis, and independent task management in a fast-paced environment with strong attention to detail and communication skills.

Qualifications

• Bachelor’s degree in a relevant scientific discipline; Ph.D. with 0-3 years acceptable.
• Hands-on experience with in vitro ADME assays preferred.
• High-throughput screening and LC/MS/MS experience preferred.
• Hamilton robotic liquid handler experience preferred.

Responsibilities

• Conduct weekly in vitro ADME assays including intrinsic clearance and CYP450 studies.
• Prepare reagents, maintain equipment, and manage supplies.
• Analyze, record, archive data, and prepare summary reports.
• Develop high-quality LC-MS/MS methods for HTADME and troubleshoot instruments.

Skills

Attention to detail

Oral and written communication

Education

Bachelor’s degree in a relevant scientific discipline

Ph.D. with 0-3 years (industry preferred)

Tools

LC-MS/MS

Hamilton robotic liquid handler

Job description

Job Summary

The Research Scientist In Vitro ADME will be responsible for the scheduling, conduct, analysis, archiving and reporting of weekly in vitro screening assays including metabolic intrinsic clearance, CYP450 inhibition and CYP450 reaction phenotyping studies

Summary of the Essential Functions of the Job

Essential functions include working in one or more of the following technical areas with appropriate supervision

• Conduct weekly discovery stage screening high throughput in vitro ADME assays, such as intrinsic clearance, protein and tissue binding, CYP450 inhibition, CYP450 reaction phenotyping and whole blood stability
• Perform routine laboratory tasks, including reagent preparation, equipment maintenance, and supply management
• With appropriate supervision, analyze, record, and archive data, prepare summary documents, and report data as needed
• Independently build high-quality LC-MS/MS methods for high throughput ADME assays. Independently identify and troubleshoot problems with the LC-MS/MS instruments or resulting data.

Minimum Requirements

• Bachelor’s degree in a relevant scientific discipline with up to 10 years of experience or a Ph.D. with 0-3 years (industry experience preferred)
• Strong preference given to candidates with hands-on experience with in vitro ADME assays
• High-throughput screening and LC/MS/MS experience preferred
• Hamilton robotic liquid handler experience preferred
• Ability to independently manage assigned tasks while meeting timelines and quality expectations in a fast-paced work environment
• Attention to detail, and effective oral and written communication skills

Kaztronix is an equal opportunity employer and does not discriminate on the basis of race, color, national origin, sex, age, religion, disability, veteran status or any other consideration made unlawful by federal, state or local laws. In addition, all human resource actions in such areas as compensation, employee benefits, transfers, layoffs, training and development are to be administered objectively, without regard to race, color, religion, age, sex, national origin, disability, veteran status or any other consideration made unlawful by federal, state or local laws.

By applying to the position, you acknowledge that your information will be used by Kaztronix in processing your application.