LCMS Scientist

Eurofins USA Discovery Services; Saint Charles (MO); On-site; USD 90,000 - 120,000; Full time

Benefits offered by this job

Full-time benefits including medical,

Dental & vision coverage

Job summary

Eurofins USA Discovery Services in Saint Charles, MO seeks an LCMS Scientist to develop LC-MS methods for ADME/DMPK, support assay development, and maintain high data quality in a GMP/GxP setting.

The ideal candidate will lead small project teams, troubleshoot MS/HPLC systems, and contribute to method validation, data management, and client-driven study delivery.

Qualifications

• Direct LC-MS/MS or LC-MS experience in ADME/DMPK.
• Experience in QA/QMS environments.
• Experience with bioanalytical method development/validation per FDA/ICH.
• Experience with small team leadership and project management.

Responsibilities

• Perform lab work in a GMP/GxP environment.
• Develop LC-MS methods for ADME/DMPK projects.
• Support internal and external project teams with new assay development.
• Troubleshoot and maintain LC-MS and HPLC systems.
• Prepare and manage buffers, reagents, and finished goods.
• Guide data QC review and assist study directors.
• Take ownership of client projects with minimal supervision.
• Support validation of new methods and expansion of service lines.
• Comply with SOPs and documentation standards.
• Provide training to colleagues and external users when required.
• Contribute to site research and development objectives.

Skills

Communication skills

Independent contributor

Reading & writing SOPs

Data analysis

Multitasking

Troubleshooting

Lab equipment proficiency

Lab software proficiency

Oral & written communication

Team collaboration

Drug discovery interest

Method development leadership

R&D project leadership

QC/data review

Education

B.S. + 5 yrs experience

M.S. + 3 yrs experience

Ph.D. + 1 yr experience

Equivalent education/experience

Tools

LC-MS

HPLC

Sciex instrumentation

Waters instrumentation

Job description

Job Description

LCMS Scientist Responsibilities & Duties Include but are not Limited to the Following:

• Performs work in a laboratory setting, meeting the physical job requirements of a lab role.


• Conducts production assays primarily in ADME Toxicology Services, but may support BioMAP®, Immunosignaling, Ion Channel, and/or OncoPanel™ Services based on business needs.


• Develops Liquid Chromatography- Mass Spectrometry (LC-MS) methods for ADME/ DMPK applications


• Develops analytical methods supporting project teams both internally and externally for new assay development.


• Performs Troubleshooting and Maintenance of Mass Spectrometers and HPLC units. Experience with Sciex® or Waters Instrumentation is a plus.


• Prepares and manages inventory of buffers, reagents, semi-finished and finished goods.


• Provides solutions to more complex problems, identifies and initiates process improvements


• Maintains high data quality and reproducibility.


• Performs data and report QC review within the department, and may support study director.


• Takes ownership of client projects with minimal supervision.


• Supports validation of new methods, and contributes to expansion of service/product line, equipment, and data management systems.


• Understands and complies with requirements for work performed at a GxP site.


• Completes required training and supports 100% of Employee Health and Safety requirements.


• Demonstrates proficiency with, care and maintenance of lab equipment and department assets.


• Conducts responsible use of confidential IT and business systems, as required.


• Adheres to department SOPs and documentation requirements, maintains accurate data management and reporting.


• Supports unit goals and demonstrates Eurofins’ competencies, as defined in the job plan.


• Provides training to colleagues and external end users, when required.


• Contributes to scientific community, and site research and development objectives.


• Works effectively in a team environment, under minimum direction, to achieve business production, project timelines, and quality objectives.


• Adjusts work hours and provides cross-functional support to other departments, as required, and maintains accountability in delivering to client needs/timelines.


• Routinely communicates project updates to internal and external clients.


• Performs other duties, as assigned/

Qualifications

• B.S. with minimum 5 years relevant laboratory experience


• M.S. with minimum 3 years relevant laboratory experience


• Ph.D. with minimum 1 year relevant laboratory experience


• Or an equivalent of education and laboratory experience

Basic Minimum Work Requirements:

• Direct experience with Liquid Chromatography- Mass Spectrometry and/or ultraviolet spectrometry (LC-MS or LC-UV) in a contract research organization or industry laboratory for ADME/ DMPK applications


• Experience working in a Quality Management System


• Scientific expertise with mass spectrometry-based quantification for ADME/ DMPK applications in biological matrices.


• Experience with analytical method development and optimization


• Familiarity with concepts of validation of bioanalytical methods in accordance with regulatory (FDA, ICH) guidelines


• Experience with liquid handling, automation, solid-phase extraction (SPE), HTS applications, and large-scale screening


• Experience in small team leadership and project management


• Experience in leading and delivering results in R&D or innovation programs


• Authorization to work in the United States indefinitely without restriction or sponsorship.

The Ideal Candidate Possesses the Following:

• Good communication and interpersonal skills


• Demonstrated proficiency in contributing independently on a project team with time and quality deliverables


• Ability to read, write, and interpret documents, such as standard operating procedures and technical reports


• Ability to perform mathematical calculations, statistical analyses, and data interpretation


• Ability to multitask with organization and manage time effectively


• Ability to solve practical problems and troubleshooting skills


• Ability to work in a laboratory setting, according to physical requirements of a laboratory role


• Lab equipment and office computer/software proficiency


• Above average oral and written communication skills


• Demonstrates a positive attitude, capacity for team environment, and exhibits a genuine interest in drug discovery in support of advancing human health


• Ability to develop new methods, and lead research and development projects


• Ability to review and QC release data/reports


• Ability to lead small, informal sub-teams, train, and train new team members


• Ability to conduct mid-size projects with minimal supervision


• Ability to contribute to strategic vision, establishment of new service lines, equipment, and data management systems


• Ability to easily support cross-functional demands

Additional Information

Position is full-time working Sunday - Thursday or Saturday - Wednesday 8:00pm - 5:00 PM. Candidates currently living within a commutable distance of St. Charles, MO are encouraged to apply.

• Excellent full-time benefits including comprehensive medical coverage, dental, and vision options


• Life and disability insurance


• 401(k) with company match


• Paid vacation and holidays

#LI-KS1

Eurofins USA Discovery Services is a Disabled and Veteran Equal Employment Opportunity employer.