Research Scientist – Antibody Discovery & Single B-Cell

Elanco; Indianapolis (IN); On-site; USD 90,000 - 150,000; Full time

Benefits offered by this job

Multiple relocation packages

Two weeklong shutdowns

8-week parental leave

Flexible work arrangements

Up to 6% 401K matching

Job summary

Elanco is seeking a Research Scientist to join the Discovery Research team in Indiana. You will lead single-B-cell antibody discovery campaigns, isolate antigen-specific B cells by FACS, and drive high-throughput sequencing and library construction to identify therapeutic candidates for animal health.

The role requires a PhD in Immunology or related field and hands-on experience with NGS, immune libraries, and cloning.

Qualifications

• PhD in Immunology, Molecular Biology, or Biotechnology with 0–3 years of relevant industrial experience.
• Hands-on experience with Single B-cell sequencing workflows and high-speed flow cytometry (FACS).
• Experience in Immune Library construction and display technologies.
• Advanced proficiency in high-throughput PCR and molecular cloning.

Responsibilities

• Lead end-to-end single-B-cell antibody discovery workflows including immune-cell processing and FACS isolation.
• Design and construct high-diversity immune libraries and perform NGS benchmarking.
• Manage complex panning and selection strategies using phage or yeast display.
• Utilize high-throughput RT-PCR and cloning to rescue heavy and light chain V-regions from single cells.
• Collaborate with bioinformatics to integrate large-scale NGS data and track repertoire dynamics.
• Represent the discovery group in cross-functional project teams communicating strategy.
• Maintain ELN documentation and present discovery data at internal forums.
• Evaluate emerging antibody discovery technologies to improve throughput and timelines.

Skills

Single B-cell sequencing

FACS

NGS library prep

Immune library construction

PCR & cloning

Education

PhD in Immunology/Molecular Biology/Biotechnology

Tools

RT-PCR

Display technologies

Job description

Elanco is seeking a Research Scientist to join the Discovery Research team in Indiana. You will lead single-B-cell antibody discovery campaigns, isolate antigen-specific B cells by FACS, and drive high-throughput sequencing and library construction to identify therapeutic candidates for animal health.

The role requires a PhD in Immunology or related field and hands-on experience with NGS, immune libraries, and cloning.