Research Scientist, Antibody Discovery (Single-Cell)

elanco; Indianapolis (IN); On-site; USD 90,000 - 130,000; Full time

Benefits offered by this job

relocation packages

2 weeklong shutdowns (mid-summer &year

8-week parental leave

9 Employee Resource Groups

Annual bonus offering

Flexible work arrangements

Up to 6% 401K matching

Job summary

Elanco in the United States is seeking a Research Scientist to join the Discovery Research team. The role focuses on capturing immune repertoires and identifying therapeutic antibody candidates for animal health using single-B-cell workflows and immune libraries.

You will lead B-cell discovery campaigns, perform immune library design, and work with phage/yeast display for selection. Strong molecular biology and NGS skills are required.

Qualifications

• PhD in Immunology, Molecular Biology, or Biotechnology with 0–3 years of industry experience.
• Hands-on single B-cell sequencing workflows and flow cytometry (FACS) experience.
• Experience with immune library construction and display technologies.
• Proficiency in high-throughput PCR and molecular cloning.

Responsibilities

• Lead end-to-end single-B-cell antibody discovery workflows, including cell processing and sequencing.
• Design and construct diverse immune libraries from immunized animals.
• Execute panning and selection using display technologies to isolate high-affinity binders.
• Rescue heavy/light chain variable regions from single cells using RT-PCR and cloning.
• Integrate NGS data with bioinformatics to identify novel lineages.
• Collaborate with cross‑functional teams and present findings at forums.

Skills

Direct hands-on experience with Single

High-speed flow cytometry (FACS)

NGS library preparation

Molecular biology techniques

Immune Library construction

Molecular cloning

Education

PhD in Immunology, Molecular Biology, or Biotechnology

Tools

FACS

NGS platforms

High-throughput PCR

Job description

Elanco in the United States is seeking a Research Scientist to join the Discovery Research team. The role focuses on capturing immune repertoires and identifying therapeutic antibody candidates for animal health using single-B-cell workflows and immune libraries.

You will lead B-cell discovery campaigns, perform immune library design, and work with phage/yeast display for selection. Strong molecular biology and NGS skills are required.