Antibody Discovery Scientist: Single B-Cell & NGS

Elanco in; Indianapolis (IN); On-site; USD 129,000 - 158,000; Full time

Benefits offered by this job

Relocation packages

Shutdowns (mid-summer/year-end)

Parental leave

Employee Resource Groups

Annual bonus

Flexible work arrangements

401K matching

Job summary

Elanco is seeking a Research Scientist to join the Discovery Research team focused on antibody discovery in biotech. The role emphasizes single B-cell sequencing and immune library construction to identify therapeutic candidates for animal health.

The candidate will lead end-to-end discovery workflows, develop diverse libraries, and integrate NGS data with bioinformatics to drive early-stage biologics development. Strong collaboration across teams is essential.

Qualifications

• PhD in Immunology, Molecular Biology, or Biotechnology with 0-3 years of relevant industrial experience.
• Direct, hands-on experience with single B-cell sequencing workflows and FACS.
• Experience with NGS library preparation and molecular biology techniques.
• Experience in Immune Library construction and display technologies.
• Proficient in high-throughput PCR and molecular cloning.

Responsibilities

• Lead and execute end-to-end single-B-cell antibody discovery workflows.
• Design and construct high-diversity immune libraries and monitor diversity.
• Manage complex panning and selection strategies using phage or yeast display to isolate rare, high-affinity binders.
• Utilize high-throughput RT-PCR, nested PCR, and cloning techniques to rescue heavy and light chain variable regions from single cells.
• Work with bioinformatics pipelines to integrate large-scale NGS datasets and analyze repertoire convergence.
• Represent the antibody discovery group in cross-functional project teams and communicate discovery screening strategy.
• Maintain ELN and present data at internal forums and stakeholder meetings.
• Evaluate and implement emerging antibody discovery technologies to improve throughput and timelines.

Skills

Single B-cell sequencing

Flow cytometry (FACS)

NGS library preparation

Immune Library construction

Display technologies

High-throughput PCR

Molecular cloning

Education

PhD in Immunology, Molecular Biology, or Biotechnology

Job description

Elanco is seeking a Research Scientist to join the Discovery Research team focused on antibody discovery in biotech. The role emphasizes single B-cell sequencing and immune library construction to identify therapeutic candidates for animal health.

The candidate will lead end-to-end discovery workflows, develop diverse libraries, and integrate NGS data with bioinformatics to drive early-stage biologics development. Strong collaboration across teams is essential.