Research Scientist 3

Massachusetts Institute of Technology; Cambridge (MA); On-site; USD 130,000 - 180,000; Full time

Job summary

The Zhang Lab at the Broad Institute of MIT and Harvard is seeking a Research Scientist 3 with expertise in proteomics and peptidomics to develop and optimize quantitative and qualitative assays supporting research in programmable therapeutics and human health.

You will prepare samples, operate LC-MS instruments, troubleshoot workflows, and analyze data using PEAKS, FragPipe, DIA-NN, and Skyline, while leading projects, guiding experimental design, and mentoring junior researchers across teams.

Qualifications

• Expertise in proteomics and peptidomics, including immunopeptidomic assays.
• Experience leading projects from concept to execution.
• Ability to design experiments and mentor junior researchers.

Responsibilities

• Prepare biological samples for MS analyses.
• Operate and maintain LC-MS instruments and troubleshoot workflows.
• Analyze mass spectrometry data using PEAKS, FragPipe, DIA-NN, and Skyline.
• Lead projects from concept through execution and contribute to research strategy.
• Collaborate across teams and mentor junior researchers.

Skills

Proteomics

Peptidomics

Mass spectrometry data analysis

LC-MS operation

Mentoring

Experimental design

Collaborative work

Tools

PEAKS

FragPipe

DIA-NN

Skyline

LC-MS instruments

Job description

RESEARCH SCIENTIST 3, The Zhang Lab - Broad Institute of MIT and Harvard, with expertise in proteomics and peptidomes. This individual will develop and optimize quantitative and qualitative proteomic, peptidomic, and immunopeptidomic assays supporting research in programmable therapeutics and human health. Key responsibilities include preparing biological samples, operating and maintaining LC-MS instruments, troubleshooting workflows, and analyzing mass spectrometry data using platforms such as PEAKS, FragPipe, DIA-NN, and Skyline. The scientist will lead projects from concept through execution, contribute to experimental design and research strategy, collaborate across teams, and mentor junior researchers.

The full job description is available, here: https://www.dropbox.com/scl/fi/lwyc355ourlsakli1a9yb/Proteomics-Research-Scientist.pdf?rlkey=9m3v8qz6ysozfad42lntkcmyu&st=8yyrb9e1&dl=0