Research Scientist

Allen Spolden; San Diego (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

San Diego, United States – Zohorecruit is seeking a scientist to design and execute experiments for the formulation and characterization of nanoparticle-based drug delivery systems. The role covers early-stage development, analytical method creation, and collaboration with cross-functional teams.

Strong hands-on experience with HPLC/UPLC, plate-based assays, and nanoparticle analytics is required, with emphasis on data-driven reporting and documentation.

Qualifications

• Degree in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Biomedical Engineering, or closely related disciplines.
• Experience with HPLC/UPLC methods and small molecule/nucleic acid/protein analysis.
• Bachelor’s, Master’s, or PhD with increasing years of relevant work as described.

Responsibilities

• Design and implement experiments for formulation and characterization of polymeric, liposomal and other nanoparticles for in vivo delivery.
• Lead and participate in early-stage nanoparticle formulation development for targeted therapies.
• Document work with scientific writing and maintain accurate records.
• Assess and develop nanoparticle formulation activities and analytical methods.
• Develop methods to analyze drug product formulations and components.
• Apply age-appropriate analytical techniques for small molecules, nucleic acids, proteins, lipids, and polymers.
• Engage in cell-based assays and related readouts as needed.
• Characterize nanoparticles physically, including particle sizing, where applicable.
• Familiarize with lab-scale nanoparticle prep, including microfluidics techniques.
• Work with automated liquid handling systems when relevant.
• Collaborate across teams and communicate results clearly.

Skills

HPLC

UPLC

Nanoformulation

Nanoparticles

Cell-based assays

Microfluidics

Analytical methods

Data analysis

Technical writing

Collaboration

Education

Degree in Chemistry / Biochemistry / Pharmaceutical Sciences / Chemical Engineering / Biomedical Engineering or closely related disciplines

Tools

HPLC/UPLC instruments

Plate reader

Field Flow Fractionation

Multi-Angle Light Scattering

Automated liquid handlers

Microfluidics equipment

Job description

San Diego, United States

1. Design and implement experiments for the formulation and characterization of polymeric, liposomal, lipid and other nanoparticles for in vivo drug delivery.

2. Lead and participate in the assessment and development of early-stage nanoparticle formulation development activities, including targeted therapies.

3. Must have hands-on experience with HPLC, UPLC equipment and methods.

4. Must have hands-on experience with plate-based assays.

5. Must have experience in development of methods to analyze and characterize drug product formulations, components, and functionality.

6. Experience and technical proficiency with HPLC and other methods for analysis and quantification of small molecules, nucleic acids, proteins, lipids, and polymers is preferred.

7. Experience with cell-based assays a plus.

8. Previous experience and technical proficiency in the physical characterization of nanoparticles, including particle sizing is a plus.

9. Familiarity with lab-scale nanoparticle preparation techniques, including microfluidics technology, is a plus.

10. Experience with automated liquid handlers is a plus.

11. Experience with field flow fractionation and multi-angle light scattering a plus.

12. Strong interpersonal, communication, collaboration, and problem-solving skills.

13. Ability to document work and proven record of scientific technical writing

Requirements

Degree in Chemistry, Biochemistry, Pharmaceutical Sciences, Chemical Engineering, Biomedical Engineering, or closely related disciplines. Prefer 0-1 years+ of relevant experience with PhD, 2-3 years+ with M.S., and 5-6 years+ with B.S.