Research Lab Technician I

2200 The Brigham and Women's Hospital, Inc.; Boston (MA); Sur place; USD 29 000 - 40 000; Plein temps

Résumé du poste

The Brigham and Women’s Hospital, Inc. in Massachusetts is seeking a Technical Research Assistant in the Department of Pathology to conduct research on blood-based biomarkers for pregnancy complications using Simoa and MOSAIC assays.

The role involves preparing reagents, running assays, and data analysis as part of a collaborative team. Responsibilities include literature review, data presentation, and contributing to manuscripts.

Qualifications

• BA/BS in biological/physical science required or equivalent.
• 1+ year lab research experience in molecular biology, biochemistry or similar preferred.
• Experience with nucleic acid analysis and/or protein biochemistry advantageous.

Responsabilités

• Independently performs routine and non-routine experiments (binding reagents, assay optimization, sample screening).
• Operates Simoa HD-X and MOSAIC instruments to analyze patient samples.
• Calculates and analyzes data using statistical techniques.
• Prepares presentations and reports; assists with manuscripts.

Connaissances

ELISA

Human subject research

Python or R

Data analysis

Documentation

Communication

Lab techniques

Troubleshooting

Formation

BA/BS in biological/physical science

Description du poste

Site: The Brigham and Women’s Hospital, Inc. Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not-for-profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high‑performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.

Job Summary

Under general supervision of the Principal Investigator and in accordance with established hospital policies and procedures, a position is open for an independent, self‑motivated, full‑time Technical Research Assistant in the Department of Pathology at Brigham and Women’s Hospital. Our laboratory identifies blood‑based biomarkers for early detection of complications of common pregnancy conditions (e.g., preeclampsia, premature rupture of membranes), and develops low‑cost, simple diagnostics suited to low‑ and middle‑income countries to help identify high‑risk pregnancies. The candidate will conduct research utilizing ultrasensitive single molecule array (Simoa) and Molecular On‑bead Signal Amplification for Individual Counting (MOSAIC) assays to measure biomarkers that conventional methods cannot detect. Specific applications may include the characterization of biomarker concentrations in blood or other bio‑fluids using assays developed using existing Simoa/MOSAIC technology or the development of new diagnostic techniques. A successful candidate will accurately prepare reagents, execute protein detection assays, and handle biological samples. The Technical Research Assistant will work as part of a research team, under general supervision, carrying out pre‑outlined experiments and designing new experiments independently when needed.

Responsibilities

1. Independently performs routine and non‑routine experiments that are moderate to complex. Experimental work may include preparing binding reagents and evaluating binding reagent viability in the assay platform, optimizing, validating, and modifying assays, screening biological samples, and preparing special materials.
2. Operates the Simoa HD‑X and MOSAIC instruments to analyze patient‑derived blood, plasma, or serum from pregnancy cohorts.
3. Calculates, transcribes, and analyzes data using moderate to advanced statistical techniques.
4. Performs literature searches, prepares presentations and progress reports, and assists in preparing manuscripts for publication. Corresponds and communicates progress professionally with collaborators and scientific community.
5. In collaboration with PI or Research Manager, establishes new and modifies existing research techniques.
6. Coordinates schedule of tests and procedures. Documents experimental work accurately and in detail.
7. Coordinates lab activities such as bio‑safety trainings.
8. Assists in the orientation and training of new staff.
9. Orders supplies and maintains laboratory inventory.
10. All other duties as assigned.

Qualifications

Education: BA/BS in biological/physical science required. At least one year of lab research experience in molecular biology, biochemistry, or similar is preferred (experience with nucleic acid analysis and/or protein biochemistry). Experience with one or more of the following is advantageous, but not required: Can this role accept experience in lieu of a degree? Yes Experience Prior laboratory experience, either through academic coursework, internships, or employment 1-2 years preferred

Knowledge, Skills and Abilities

• ELISA
• Human subject research and/or BSL2 practices
• Programming experience (Python or R) for computational analysis of large biological datasets
• Programming of liquid handling robots
• Sound analytical and organizational skills
• High degree of computer literacy.
• Requires good oral and written communication skills
• Ability to logically and effectively structure tasks and set priorities
• Ability to identify potential problems and trouble‑shoot solutions.
• Ability to accurately document, analyze, and interpret experimental data.
• Ability to work both independently and collaboratively in a multidisciplinary research environment.
• Strong attention to detail and ability to perform quantitative laboratory procedures accurately.

Additional Job Details (if applicable)

Remote Type: Onsite Work Location: 60 Fenwood Road. Scheduled Weekly Hours: 40. Employee Type: Regular. Work Shift: Day (United States of America). Pay Range: $21.00 - $29.01/Hourly. Grade: 5. At Mass General Brigham, we believe in recognizing and rewarding the unique value each team member brings to our organization. Our approach to determining base pay is comprehensive, and any offer extended will take into account your skills, relevant experience if applicable, education, certifications and other essential factors. The base pay information provided offers an estimate based on the minimum job qualifications; however, it does not encompass all elements contributing to your total compensation package. In addition to competitive base pay, we offer comprehensive benefits, career advancement opportunities, differentials, premiums and bonuses as applicable and recognition programs designed to celebrate your contributions and support your professional growth.

EEO Statement

EEO Statement: 2200 The Brigham and Women’s Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and TitleI of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.

Mass General Brigham Competency Framework

At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People‑Focused, half Performance‑Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. Combat disease. Hold a hand. Help people. Impact the world.

Company Culture

Mass General Brigham is a passionate, welcoming community where minds meet caring hearts. Come be a part of the world’s most powerful force in medicine, where every role is important in changing lives. Our history includes New England hospitals founded over 200 years ago, some of the first and most prestigious hospitals in the world. Built on the legacy of two leading academic medical centers, we’re more than a system—we’re leaders in the practice of medicine. Mass General Brigham is committed to serving the community. We are dedicated to enhancing patient care, teaching and research, and taking a leadership role as an integrated health care system. We recognize that increasing value and continuously improving quality are essential to maintaining excellence.