Research Associate- Structural Biologist

Phase2 Technology; Austin (TX); On-site; USD 54,000 - 66,000; Full time

Job summary

A leading research institution in Austin is seeking a Research Associate in Structural Biology. The role involves carrying out research on reverse transcriptase and related enzymes, purifying proteins, and preparing manuscripts. Ideal candidates will possess a Ph.D. in structural biology or biochemistry, alongside relevant research experience. This position offers a competitive salary starting at $60,000, depending on qualifications, and involves mentoring graduate students and conducting biochemical assays. Personal protective equipment will be provided and may require working around chemicals and bio-hazards.

Qualifications

• Ph.D. in structural biology and/or biochemistry with demonstrated productivity.
• At least five years’ experience in research on nucleic acid-binding enzymes preferred.

Responsibilities

• Express and purify proteins for structural analysis.
• Characterize proteins biochemically and obtain structures via X-ray diffraction.
• Write manuscripts and reports, assist in student mentoring.

Skills

Structural biology

Biochemistry

Enzymatic assays

Protein characterization

Education

Ph.D. in structural biology and/or biochemistry

Tools

FPLC

X-ray diffraction

Cryo-electron microscopy

Job description

Research Associate- Structural Biologist

Job Posting Title: Research Associate- Structural Biologist

Hiring Department: Molecular Biosciences

Location: Austin, TX

Weekly Scheduled Hours: 40

Earliest Start Date: Immediately

Position Duration: Expected to Continue

Job Details

Carry out research in structural biology and biochemistry of reverse transcriptase and related enzymes and their nucleic acid complexes.

Responsibilities

• Express, purify, and characterize full-length and deletion constructs of group II intron and other non‑LTR retroelement reverse transcriptase and related proteins for structural analysis and biotechnological applications using FPLC and other methods. Characterize wild‑type and mutant proteins biochemically via enzymatic assays and determine conditions for obtaining diffraction‑quality crystals and/or for cryo‑electron microscopy analysis of proteins and protein/nucleic acid complexes. Carry out biochemical and biophysical assays.
• Obtain structures of reverse transcriptase and related enzymes and their nucleic acid‑protein complexes by X‑ray diffraction and/or cryo‑EM.
• Write manuscripts and assist in the preparation of reports, abstracts, manuscripts and proposals. Make presentations at lab meetings. Order chemicals and supplies for current projects.
• Provide instruction, assistance and mentoring to graduate students.

Required Qualifications

• Ph.D. in structural biology and/or biochemistry with demonstrated productivity in these areas.
• Relevant education and experience may be substituted as appropriate.

Preferred Qualifications

• Ph.D. in structural biology and/or biochemistry with at least five years’ experience and demonstrated research productivity on enzymes that bind nucleic acids and/or protein‑nucleic acid complexes.

Salary Range

$60,000 + depending on qualifications

Working Conditions

• Personal protection equipment (furnished).
• May work around chemical fumes.
• May work around standard office conditions.
• May work around bio‑hazards.
• May work around chemicals.

Required Materials

• Current curriculum vitae.
• Three letters of reference, at least two from referees outside of The University of Texas at Austin.
• Letter of interest.

Equal Opportunity Employer

The University of Texas at Austin is an equal opportunity/affirmative action employer, complying with all applicable federal and state laws. The University is committed to a policy of equal opportunity for all persons and does not discriminate on the basis of race, color, national origin, age, marital status, sex, sexual orientation, gender identity, gender expression, disability, religion, or veteran status in employment, educational programs and activities, and admissions.