Research Associate I/II I-O

SystImmune, Inc.; Washington (District of Columbia); On-site; USD 60,000 - 80,000; Full time

Job summary

SystImmune, Inc. in Redmond, WA (onsite now, moving to Bothell in fall 2026) is seeking a Research Associate I/II to join the Bioassay team within the Immuno-Oncology department.

The role focuses on engineering complex cell lines and executing cell-based immunoassays to enable discovery and development of novel cancer therapeutics. The successful candidate will be a hands-on experimentalist with experience in genetic modification (lentiviral transduction and knock-ins/outs) and immunoassay

Qualifications

• BS or MS in Biology, Immunology, Cell Biology, Bioengineering, Biochemistry, or related scientific field
• Minimum 1+ year of industry laboratory experience (internships may be considered if highly relevant)
• Hands-on experience with mammalian cell culture techniques and aseptic techniques
• Exposure to genetic modification workflows such as lentiviral transduction
• Basic familiarity executing immunoassays such as ELISA or flow cytometry
• Strong organizational skills and attention to detail
• Ability to work effectively in a team environment
• Research Associate II: typically 2–4 years of relevant industry experience, direct cell-line engineering experience

Responsibilities

• Engineer stable cell lines using lentiviral transduction, CRISPR knock-ins, and knock-outs
• Analyze complex datasets, prepare technical reports, and present findings to internal teams
• Perform rigorous batch qualification of critical reagents and cell lines to ensure assay consistency
• Maintain and manipulate complex co-cultures of primary immune cells and engineered cancer cell lines
• Conduct functional assays using IncuCyte live-cell imaging, flow cytometry, and ELISA-based platforms
• Develop, optimize, and validate cell-based and immunoassays to support drug development programs

Job description

SystImmuneis a leading and well-funded clinical-stage biopharmaceutical company located in Redmond, WA and Princeton, NJ. It specializes in developing innovative cancer treatments using its established drug development platforms, focusing on bi-specific, multi-specific antibodies, and antibody-drug conjugates (ADCs).SystImmunehas multiple assets in various stages of clinical trials for solid tumor and hematologic indications. Alongside ongoing clinical trials.SystImmunehas a robust preclinical pipeline of potential cancer therapeutics in the discover and IND-enabling stages, representing cutting-edge biologics development. We offer an opportunity for you to learn and grow while making significant contributions to the company's success.SystImmuneInc. is seeking a motivated ResearchAssociateI/II to join the Bioassay team within the Immuno-Oncology department.This role will support the engineering of complex cell lines and the execution of cell-basedimmunoassays to enable the discovery and development of novel cancer therapeutics. The ideal candidate will be a strong experimentalist with direct experience in genetic modification (such as lentiviral transduction and knock-in/out) and bioassay execution who thrives in a fast-paced, collaborative environment.

This is a hands-on laboratory role focused on critical materials generation, assay execution, and data analysis. The successful candidate willmaintainhigh-quality experimental standards while developing deep technicalexpertisein immuno-oncology drug development.

This role is full-time onsite in Redmond, WA and will move to Bothell, WA fall 2026.

Key Responsibilities

• Engineer stable cell lines using lentiviral transduction, CRISPR knock-ins, andknock-outs
• Analyze complex datasets, prepare technical reports, and present findings to internal teams.
• Perform rigorous batchqualificationof critical reagents and cell lines to ensure assay consistency.
• Maintain and manipulate complex co-cultures of primary immune cells and engineered cancer cell lines.
• Conduct functional assays usingIncucytelive-cell imaging, flow cytometry, and ELISA-based platforms.
• Develop,optimize, andvalidatecell-based and immunoassays to support drug development programs.

Qualifications

• Research Associate I:
  • BS or MS in Biology, Immunology, Cell Biology,Bioengineering,Biochemistry, or related scientific field
  • Minimum 1+ year of industry laboratory experience (internships may be considered if highly relevant)
  • Hands-on experience with mammalian cell culture techniques and aseptic techniques
  • Experience with mammalian cell culture techniques
  • Exposure to genetic modification workflows such as transient transfections or lentiviral transduction
  • Basic familiarity executing immunoassays such as ELISA or flow cytometry
  • Strong organizational skills and attention to detail
  • Ability to work effectively in a team environment
• Research Associate II:
  • BS or MS in a relevant scientific discipline
  • Typically, 2–4 years of relevant industry experience
  • Direct experience engineering cell lines, including executing lentiviral transductions and knock-ins
  • Proven track record executing and troubleshooting cell-based assays and flow cytometry workflows
  • Demonstrated ability to work with moderate independence

Preferred Qualifications

• Experience supporting oncology, immuno-oncology, immunology, orbiologicsdrug discovery programs.
• Experience with single-cell cloning, CRISPR/Cas9 workflows, or stable cell lineselection.
• Proficiency with Incucytelive-cell imaging, multi-color flow cytometry, or MSD multiplex platforms.
• Exposure to high-throughput research settings or regulated laboratory environments.
• Strong data analysis software skills (e.g., GraphPad Prism,FlowJo) and scientific communication skills

Compensation and Benefits

The expected base salary range for this position is 60,000 - 80,000 annually. Actual compensation will be based on a variety of factors, including but not limited to a candidate’s level qualifications, experience, and skills. While most offers typically fall within the low to mid-pointof the range, we may extend an offer toward the higher end for exceptional candidates whose background and expertise exceeds the requirements of the role.

SystImmuneis a leading and well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success.

SystImmuneoffers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmuneoffers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmuneis an Equal Opportunity Employer. We welcome diverse talent and encourage all qualified applicants to apply.