Research Associate I/II, Formulation and Analytical Chemistry

Wave Life Sciences; Lexington (MA); On-site; USD 60,000 - 90,000; Full time

Job summary

An innovative biotechnology company is seeking a motivated Research Associate to contribute to groundbreaking RNA medicine research. This role involves analyzing oligonucleotides, operating advanced laboratory equipment, and ensuring sample quality for critical discovery activities. The ideal candidate will thrive in a fast-paced, collaborative environment, bringing strong analytical skills and a background in chemistry. With a commitment to transforming human health, this position offers a unique opportunity to be part of a team that is reimagining the possibilities of RNA therapies.

Qualifications

• 0-4 years of industry experience in analytical chemistry.
• Strong preference for candidates with experience in LC-MS and UHPLC.

Responsibilities

• Fulfill compound requests for in vitro/vivo assays.
• Analyze oligonucleotides using LC-MS and UHPLC.
• Mentor co-ops and maintain laboratory instruments.

Skills

Analytical Chemistry

LC-MS

UHPLC

Attention to Detail

Time Management

Problem-solving

Laboratory Operations

Pipetting

Education

Master's Degree in Chemistry

Bachelor's Degree in Chemistry

Tools

Hamilton Star Liquid Handler

Job description

Job Description

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington's disease, as well as a preclinical program in obesity. Driven by the calling to "Reimagine Possible", we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description:

Wave Life Sciences seeks a motivated Research Associate I/II, Formulation and Analytical Chemistry, to join our team in Lexington, MA. This is an ideal position for an individual with a background in analytical chemistry who thrives in a team-oriented, fast-paced, biotech environment. This candidate will be responsible for fulfilling compound requests to support Discovery-related activities and ensuring sample quality.

Responsibilities:

• Enable timely fulfillment of compound requests while ensuring their accuracy and quality for in vitro/vivo assays
• Analysis of oligonucleotides by LC-MS and UHPLC for identification and purity assessment
• Operation of Hamilton Star liquid handler for high throughput sample preparation in 96-well assay plates
• Perform QC assays such as UV, pH, osmolality, and bacterial endotoxin
• Maintain an accurate and traceable oligonucleotide inventory
• Mentor co-ops on laboratory instrumentation and workflows
• Support general laboratory instrument maintenance and troubleshooting
• Communicate effectively with team members and requestors to enable screening efforts for multiple projects
• Document experimental results in ELN and register relevant sample data
• Interact with Data Science/IT to continually advance the data management systems as needed

Key Skills:

• Meticulous attention to detail and data integrity
• Excellent organizational and time management skills with ability to multitask
• Excellent communication and problem-solving skills
• Expertise with common laboratory operations, including accurate pipetting, dilution, and UV measurement
• Previous experience with UHPLC and LC-MS operation and analysis strongly preferred

Education / Experience:

• Masters Degree with 0-2 years of industry experience or Bachelor's Degree with 2-4 years of industry experience
• Analytical chemistry background preferred

Wave Life Sciences provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Wave Life Sciences complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Wave Life Sciences expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status. Improper interference with the ability of Wave Life Sciences' employees to perform their job duties may result in discipline up to and including discharge.

We value our relationships with professional recruitment firms. To protect the interests of all parties, and given the large volume of inquiries received from third-party placement agencies, we are not able to respond to all agency inquiries. We do not accept unsolicited resumes from any source other than directly from candidates for current or future positions. Submission of unsolicited resumes in advance of a signed agreement between our company and a placement agency does not create an implied obligation and, if an unsolicited candidate represented by a placement agency is hired, we are not obligated to pay a fee. Only approved recruitment firms will be allowed to provide services to Wave Life Sciences, USA.