Scientist I/II – Biologics Generation and Analytics

PharmaEssentia U.S.A.; Bedford (MA); On-site; USD 70,000 - 110,000; Full time

Job summary

Join a forward-thinking biopharmaceutical company dedicated to innovative therapies in oncology and immunology. As a Scientist in Biologics Generation and Analytics, you'll play a crucial role in developing novel biotherapeutics. Collaborate with a talented team to design, express, and purify recombinant proteins while utilizing cutting-edge biophysical techniques. Your expertise will help advance drug discovery programs and contribute to groundbreaking research that aims to improve the lives of cancer patients. This is a unique opportunity to make a significant impact in a dynamic and supportive environment.

Qualifications

• PhD in Biochemistry with 2+ years in Biologics discovery.
• Hands-on experience in mammalian expression systems.

Responsibilities

• Design and purify recombinant proteins for research programs.
• Lead analytical assessments using techniques like HPLC and ELISA.

Skills

Biologics discovery

Protein expression systems

Protein purification techniques

Analytical techniques

Collaboration

Education

PhD in Biochemistry

Tools

AKTA systems

HPLC

SDS-PAGE

Job description

Scientist I/II – Biologics Generation and Analytics

About the job

PharmaEssentia is a global biopharmaceutical company dedicated to developing innovative therapies to address unmet medical needs in oncology, hematology, and immunology. With a strong foundation in disease biology, biologics, and translational science, we are expanding our research capabilities to drive the next generation of therapeutic breakthroughs. We are seeking a highly motivated and skilled scientist to join our Biologics Platform team in the role of Scientist, Biologics Generation and Analytics. This position focuses on recombinant protein expression and purification, as well as performing comprehensive protein analysis, developability, and stability assessments using state-of-the-art biophysical techniques. The successful candidate will support the discovery and development of novel biotherapeutics, including antibodies, cytokines, engineered multi-functional proteins, and antibody-drug conjugates (ADCs). The ideal candidate will have strong technical expertise in protein expression systems, purification strategies, and biophysical/biochemical characterization methods, combined with a collaborative and solution-oriented approach to advancing our biologics pipeline.


Responsibilities

• Design, express, and purify recombinant protein and biologics (e.g., cytokine, antibodies, multi-specific formats, fusion proteins) to support PharmaEssentia’s research and early development programs.
• Lead analytical, developability, and stability assessment of biologics using techniques such as SDS-PAGE, HPLC, SEC, BLI/SPR, and ELISA to assess purity, binding, and CMC properties.
• Develop, optimize, and troubleshoot protocols for biologics generation and analytics workflows, ensuring high-quality and reproducible results.
• Provide technical expertise, guidance, and mentorship to junior team members, cultivating an environment of continuous learning and growth.
• Participate in project teams, identify and prioritize critical experiments to accelerate the drug discovery programs, and contribute to an innovative product portfolio with diverse modalities.
• Constantly assess and implement new technology to the existing workflow to improve efficiency and to enhance biologics production and analytical capabilities.

Qualification

• PhD in Biochemistry, or related biological science disciplines with 2+ year post-graduate experience in Biologics discovery and development function.
• Hands-on experience in biologics production using mammalian expression systems (e.g., transient/stable transfection in HEK293 or CHO cells).
• Proficiency in protein purification techniques including affinity, ion exchange, and size-exclusion chromatography.
• Expertise in protein analytical techniques such as UV-VIS, SEC-HPLC, RP-HPLC, CE-SDS, cIEF/IEX DLS, and DSF.
• Experience in protein purification using automated (AKTA) systems and purification of constructs with appropriate tags.

Preferred Qualification

• Hands-on experience with antibody engineering, multi-specific antibody formats, or Fc-fusion protein generation.
• Knowledge of developability assessments and early characterization assays for biologics.
• Familiarity with bioconjugation, purification and characterization processes relevant to ADC development and manufacturing.
• Experience using automation platforms for high-throughput protein expression, purification, and analytical workflows.

EEO Statement:
At PharmaEssentia Innovation Research Center (PIRC), we are committed to providing an environment of mutual respect where equal employment opportunities are available to all applicants without regard to race, color, religion, sex, pregnancy (including childbirth and related medical conditions), national origin, age, physical and mental disability, marital status, sexual orientation, gender identity, gender expression, genetic information (including characteristics and testing), military and veteran status, and any other characteristic protected by applicable law. PIRC believes that diversity and inclusion among our team are critical to our success as a global company, and we seek to recruit, develop and retain the most talented people from a diverse candidate pool. PIRC does not accept unsolicited agency resumes. Staffing agencies should not send resumes to our HR team or to any PIRC employees. PIRC is not responsible for any fees related to unsolicited resumes from staffing agencies.

At PharmaEssentia, our goal is to treat as many people with cancer as possible. That means challenging the status quo with better science that leads to better lives. By joining our team, you will not only expand your own possibilities, but you will contribute to expanding options for people with cancer.

https://us.pharmaessentia.com/careers/