Scientist I/II - Integrative Biology

Sail Biomedicines; Cambridge (MA); On-site; USD 60,000 - 100,000; Full time

Job summary

Join a forward-thinking company at the forefront of programmable medicines as a Scientist I/II in Integrative Biology. In this dynamic role, you'll collaborate with a diverse team of experts to develop and scale innovative assays for RNA medicines. Your scientific initiative and teamwork will be crucial in a fast-paced environment dedicated to groundbreaking research. This lab-based position focuses on hands-on experimentation, optimizing assays, and generating critical data for in vivo studies. If you're passionate about transforming healthcare through science, this opportunity is perfect for you.

Qualifications

• PhD in immunology, microbiology or a closely related field required.
• Strong background in experimental design and data analysis is essential.

Responsibilities

• Build Sail’s core technological platform and discover novel therapeutics.
• Optimize and standardize serology and molecular assays.

Skills

Experimental Design

Data Analysis

Communication Skills

Serology Assays

Cell-Based Assays

Education

PhD in Immunology

PhD in Microbiology

Tools

Flow Cytometry

ELISA

Luminex Assays

Data Analysis Software

Job description

Title:

Scientist I/II Integrative Biology

Manager:

Principal Scientist, Integrative Biology

Type:

Onsite

About Sail:

Sail Biomedicines is harnessing evolutionary and artificial intelligence to revolutionize programmable medicines. Sail’s platform combines first-in-class programmable RNA technology (Endless RNATM or eRNA), and an industry-leading platform of programmable nanoparticles, utilizing natural components, to unlock comprehensive programming of medicines for the first time. By leveraging cutting-edge eRNA and nanoparticle deployment technology, Sail is building a wealth of data, enabling unparalleled use of AI techniques to identify and design fully programmable medicines that are potent, targeted, versatile, and tunable. Sail was founded by Flagship Pioneering.

The Role:

Sail Biomedicines is seeking a highly motivated Scientist I/II to join the Integrative Biology group at Sail Biomedicines. Collaborating with an interdisciplinary team experienced in molecular biology, bioengineering, pharmacology, data science, and machine learning, this individual will develop and scale robust assays to discover the next generation of RNA medicines. The ideal candidate will bring a track record of scientific initiative and a deep commitment to teamwork to the Integrative Biology group’s fast-paced culture of scientific rigor.

This lab-based onsite position requires the majority of time to be dedicated to hands-on lab work, focusing on experimental tasks and collaboration within the team to drive project success.

Responsibilities:

1. Help us build Sail’s core technological platform and discover novel therapeutics.
2. Operate outside your scientific comfort zone to lead and support multiple projects from ideation through execution.
3. Optimization and standardization of serology and molecular assays.
4. Generate endpoint data for in vivo studies including, but not limited to, flow cytometry and molecular assay readouts.
5. Assist other team members in performing laboratory experiments as needed.
6. Maintain accurate and up-to-date laboratory notebooks.

Qualifications:

1. PhD in immunology, microbiology or a closely related field.
2. Strong background in experimental design, data analysis, and interpretation.
3. Effective communication with both technical and non-technical audiences.
4. Proficiency in developing and performing serology and cell-based assays.
5. Ability to work effectively with minimal direction and oversight.

Desired Qualifications:

1. Experience in conducting preclinical vaccine studies and processing animal tissue samples.
2. Experience in cell and tissue culture experiments, serology assays (ELISAs, bead-based Luminex assays), T cell assays (flow cytometry based immunophenotyping, intracellular cytokine assays and ELISPOT). Experience with automation would be an asset.
3. Solid grounding in data analysis and statistics.

Sail Biomedicines is an Equal Opportunity Employer. Sail does not discriminate on the basis of race, religion, color, sex, gender identity, sexual orientation, age, national origin, veteran status, or any other status protected under federal, state, or local law.