Remote Real-World Evidence & HEOR Lead

El Camino Health; Northern (KY); Hybrid; USD 115,000 - 149,000; Full time

Job summary

iRhythm Technologies is seeking a Real World Evidence Manager to lead analytical workstreams across RWE, HEOR, and health economics, delivering outputs that inform payer coverage, health system contracting, and product strategy. You will design retrospective/prospective studies, build economic models, and publish findings while mentoring junior analysts, collaborating with Medical Affairs, Clinical Research, and Commercial teams.

Remote US-based role with strong methodological rigor.

Qualifications

• Masters or doctoral degree in Health Economics, Epidemiology, Biostatistics, Public Health, or a highly quantitative related field.
• 3+ years of progressive experience in HEOR, RWE, or health economic analytics within the pharmaceutical, biotech, diagnostics, or digital health industry (or equivalent academic/consulting background).
• Expert‑level proficiency in at least two of: R, Python, SAS, STATA for statistical analysis and data management.
• Demonstrated experience designing and executing observational studies using claims or EMR data.
• Strong track record of health economic model development (BIM, CEA, cost‑utility models).
• Peer‑reviewed publication record or equivalent demonstrated scientific output (abstracts, posters, dossier contributions).
• Strong analytical judgment and ability to execute rigorous analyses and communicate methodological choices clearly.

Responsibilities

• Manage the execution of retrospective and prospective RWE studies using claims data (Medicare, Medicaid, commercial), EMR/EHR data, and proprietary iRhythm clinical datasets.
• Operationalize study protocols, analytic plans, variable definitions, and statistical methodologies appropriate for payer and peer‑reviewed audiences.
• Apply advanced epidemiological methods including propensity score matching, instrumental variables, difference‑in‑differences, interrupted time series, and survival analysis.
• Ensure reproducibility, auditability, and documentation of all analytical pipelines.
• Build and maintain sophisticated health economic models including budget impact models (BIMs), cost‑effectiveness models, and payer decision‑support tools.
• Translate clinical evidence into economic inputs with appropriate uncertainty characterization.
• Develop and update payer‑facing economic tools that field and account teams can deploy in customer engagements.
• Conduct sensitivity analyses, scenario modeling, and probabilistic analyses (PSA) consistent with HTA standards.

Skills

RWE analysis

Health economics

Observational studies

Statistical programming

Cross-functional leadership

Education

MS/MPH/PhD in HEOR or related

Tools

R

Python

SAS

STATA

Job description

iRhythm Technologies is seeking a Real World Evidence Manager to lead analytical workstreams across RWE, HEOR, and health economics, delivering outputs that inform payer coverage, health system contracting, and product strategy. You will design retrospective/prospective studies, build economic models, and publish findings while mentoring junior analysts, collaborating with Medical Affairs, Clinical Research, and Commercial teams.

Remote US-based role with strong methodological rigor.