Remote QSP/QST Scientist II — Model-Informed Drug Development

Simulations Plus, Inc.; United States; Remote; USD 110,000 - 150,000; Full time

Job summary

Simulations Plus, a global leader in model-informed and AI-accelerated drug development, seeks a Scientist II to execute consulting projects using QSP/QST models and MATLAB/THALES stack. Remote work is available with flexible schedules and a strong, supportive culture.

Responsibilities include building sub-models, translating PD/MoA data to model parameters, and leading project activities while advancing R&D efforts in QST liver injury modeling. Travel as needed.

Qualifications

• 2+ years of QSP/QST modeling experience or demonstration of the equivalent skill sets
• Proficiency in mathematics, dynamic systems, drug development
• General knowledge of relevant therapeutic areas, including clinical endpoints and underlying biology
• Experience with MATLAB, THALES, Julia, SimBiology, Monolix, GastroPlus™, and/or C++ programming
• Experience with PBPK, PK, popPK and/or PKPD modeling
• Basic familiarity with large-language models and agentic AI
• Understanding of how to apply modeling and simulation for maximum impact
• Strong verbal and written communication skills
• Maintains a positive attitude while interacting with colleagues and clients
• Must be able to multitask and have good organizational skills
• Self-motivated with ability to work with minimal supervision
• Occasional travel for conferences, meetings, and training

Responsibilities

• Design, write, test, and use computer code to build and maintain the sub-model(s), representing core cellular, molecular, and/or biochemical processes in a given model
• Represent compound pharmacodynamics (PD) and/or mechanism of action (MoA), including translating laboratory data into model parameters and curation of clinical data for calibration/validation
• Learn and effectively utilize company agentic AI solutions for technical work
• Contribute to the activities required for successful completion of all goals within consulting projects
• Contribute (as time allows) to R&D efforts, including updating the “license-ready” versions of the various models and supporting ongoing development of QST models of liver injury (i.e., the DILI-sim consortium)
• Combine technical and project management work, including components such as systems pharmacology modeling, software code development, and maintenance in designated software environments
• Develop plans to complete all tasks and provide all deliverables within a time frame consistent with the services agreement signed with the sponsor
• Schedule the necessary meetings including internal and external collaborators
• Exert leadership in the areas of presentation and report preparation by exhibiting strong skills for effective presentations and reports, applying diligent scientific review, and being timely with execution and responses to feedback
• Lead consulting projects, upon demonstrating the necessary technical and project management skills and availability of a suitable project
• Participate in preparation and review of joint manuscripts between the company and the sponsor
• Manage the effort expended for a given project to remain consistent with the resources allocated for the project per the signed contract
• Publish work in scientific journals, with minimal review required by their supervisor, including documentation preparation, text development, figure development, and correspondence with editors and peer reviewers
• Train others on QSP/QST and the various models
• Other duties as assigned

Skills

QSP/QST modeling

Mathematics & dynamic systems

Communication skills

Self-motivated

Education

Master's degree in pharmaceutical science or biomedical engineering

PhD in pharmaceutical science or biomedical engineering (preferred)

Tools

MATLAB

THALES

Julia

SimBiology

Monolix

GastroPlus

C++ programming

Job description

Simulations Plus, a global leader in model-informed and AI-accelerated drug development, seeks a Scientist II to execute consulting projects using QSP/QST models and MATLAB/THALES stack. Remote work is available with flexible schedules and a strong, supportive culture.

Responsibilities include building sub-models, translating PD/MoA data to model parameters, and leading project activities while advancing R&D efforts in QST liver injury modeling. Travel as needed.