Remote Principal Engineer, AI for High-Throughput Screening

Johnson Johnson; United States; Remote; USD 117,000 - 201,000; Full time

Job summary

Johnson & Johnson Innovative Medicine seeks a Principal Engineer to lead high-throughput screening software/AI efforts for pooled and arrayed workflows in cell & genetic medicines. You will architect scalable, production-grade solutions spanning lab automation, data pipelines, APIs, and visualization tools.

You will mentor scientists and engineers, partnering across IT and Discovery Research to advance AI-enabled capabilities while meeting rigorous quality and regulatory standards.

Responsibilities

• Serve as the senior software and AI technical expert for Cell & Genetic Medicines high-throughput screening capabilities, both pooled and arrayed.
• Define and implement scalable architecture connecting laboratory automation, analytical instruments, enterprise systems, scientific data, and user workflows.
• Build reliable applications, APIs, data pipelines, computational tools, and user-facing visualization solutions for cell therapy discovery.
• Develop and deploy AI-enabled capabilities, including machine learning, generative AI, retrieval-augmented generation, and agentic workflows.
• Proactively identify and prioritize opportunities to apply AI or software solutions that improve organizational effectiveness, scientific productivity, operational efficiency, and decision-making.
• Translate complex experimental processes and scientific questions into intuitive, maintainable, and reproducible digital solutions.
• Help organize and contextualize screening data, construct information, assay metadata, and analytical outputs to improve experimental planning, data quality, hit identification, candidate ranking, and knowledge capture.
• Establish engineering best practices for architecture, development, testing, documentation, version control, deployment, observability, security, and lifecycle management.
• Build trusted cross-functional and cross-departmental partnerships across Discovery Research, IT, Business Technology, and other groups; align stakeholders, clarify expectations, and communicate decisions, risks, tradeoffs, and progress constructively.
• Influence technical direction without direct authority and mentor scientists and engineers in software engineering, data architecture, and the responsible use of AI.

Job description

Johnson & Johnson Innovative Medicine seeks a Principal Engineer to lead high-throughput screening software/AI efforts for pooled and arrayed workflows in cell & genetic medicines. You will architect scalable, production-grade solutions spanning lab automation, data pipelines, APIs, and visualization tools.

You will mentor scientists and engineers, partnering across IT and Discovery Research to advance AI-enabled capabilities while meeting rigorous quality and regulatory standards.