Quantitative Pharmacology & Pharmacometrics Lead — Cardiometabolic

Merck; Boston (MA); Hybrid; USD 157,000 - 247,000; Full time

Job summary

Merck & Co., Inc. is seeking an Associate Director to lead quantitative pharmacology efforts within the QP2 department in support of cardiometabolic pipelines.

You will develop model-based strategies, perform translational PK/PD analyses, and guide dose selection and trial design across discovery and development programs. The role emphasizes collaboration across disciplines, regulatory awareness, and independent work within a research-driven biopharmaceutical environment.

Qualifications

• Ph.D. or equivalent degree with at least 4 years of relevant experience; PharmD or equivalent with at least 6 years; MS with at least 8 years.
• Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical or biomedical engineering, or related quantitative discipline.
• Experience conducting population PK and PK/PD analyses using standard pharmacometrics software.
• Strong written and verbal communication skills with cross-disciplinary collaboration.

Responsibilities

• Develop and apply model-based strategies to inform quantitative decision-making across development programs.
• Represent QP2 on cardiometabolic discovery, early and late clinical development teams.
• Partner with external vendors and strategic partners to build model-informed approaches for drug discovery, development, and regulatory decisions.
• Collaborate across disciplines on study design, execution, data interpretation, and reporting of results.
• Maintain understanding of regulatory expectations and contribute to regulatory submissions.

Skills

Business Intelligence

Database Design

Data Engineering

Data Modeling

Data Science

Data Visualization

Machine Learning

Software Development

Stakeholder Management

Waterfall Model

Education

PhD or PharmD or MS with relevant experience

Biopharmaceutics/Pharmaceutical Sciences/Pharmacometrics background

Tools

R

Matlab

Phoenix

NONMEM

Monolix

Job description

Merck & Co., Inc. is seeking an Associate Director to lead quantitative pharmacology efforts within the QP2 department in support of cardiometabolic pipelines.

You will develop model-based strategies, perform translational PK/PD analyses, and guide dose selection and trial design across discovery and development programs. The role emphasizes collaboration across disciplines, regulatory awareness, and independent work within a research-driven biopharmaceutical environment.