Cardiometabolic Quantitative Pharmacology - Associate Director

Merck; Rahway (NJ); Hybrid; USD 157,000 - 247,000; Full time

Benefits offered by this job

Medical, dental, vision insurance

401(k) retirement plan

Job summary

Merck is seeking an Associate Director for Quantitative Pharmacology and Pharmacometrics (QP2) to lead model-based strategies across cardiometabolic programs. You will drive translational PK/PD analyses, population PK/PD modeling, and clinical trial simulations to inform dose selection and study design.

In this role, you will collaborate with discovery, early and late development teams, and external partners, contributing to regulatory submissions and decision-making.

Qualifications

• Ph.D. or equivalent degree with at least 4 years of relevant experience; PharmD or equivalent degree with at least 6 years of relevant experience; or MS or equivalent degree with at least 8 years of relevant experience.
• Educational background in biopharmaceutics, pharmaceutical sciences, pharmacometrics, chemical or biomedical engineering, or a related quantitative discipline.
• Experience conducting population PK and PK/PD analyses using standard pharmacometrics software such as R, Matlab, Phoenix, NONMEM, Monolix, or similar tools.
• Strong written and verbal communication skills, with demonstrated ability to collaborate across disciplines, scope complex problems, and plan work effectively.
• Knowledge in modeling complex therapeutics, mechanistic modeling/ QSP.

Responsibilities

• Develop and apply model-based strategies, including translational PK/PD approaches, mechanistic models, population PK/PD analyses, and clinical trial simulations.
• Represent QP2 on cardiometabolic discovery, early clinical development, and late clinical development teams.
• Partner with functional area colleagues, external vendors, and strategic partners to build aligned, model-informed approaches.
• Collaborate across disciplines on study design, protocol development, study execution, data interpretation, reporting, and communication of results.
• Maintain understanding of global regulatory expectations and contribute to regulatory documents and submissions.
• Work closely with pharmacometrics colleagues to provide scientific input on modeling strategies, analyses, interpretation, and reporting.

Skills

BI

Database Design

Data Engineering

Data Modeling

Data Science

Data Visualization

ML

Software Development

Stakeholder Mgmt

Waterfall Model

Education

PhD or equivalent

PharmD or equivalent

MS or equivalent

Tools

R

Matlab

Phoenix

NONMEM

Monolix

Job description

Merck is seeking an Associate Director for Quantitative Pharmacology and Pharmacometrics (QP2) to lead model-based strategies across cardiometabolic programs. You will drive translational PK/PD analyses, population PK/PD modeling, and clinical trial simulations to inform dose selection and study design.

In this role, you will collaborate with discovery, early and late development teams, and external partners, contributing to regulatory submissions and decision-making.