QSP Postdoc: AI-Driven PK/PD Modeling for Discovery

BioSpace

Boston (MA)

On-site

USD 58,000 - 123,000

Full time

13 days ago

Application generator

Don’t send a generic resume — generate a resume and cover letter tailored to this exact role.

Get past ATS filters

Benefits offered by this job

401(k) plan

Pension

Vacation benefits

Medical, dental, vision benefits

Flexible benefits

Life insurance

Job summary

Lilly is seeking a highly motivated postdoctoral scientist to join the Global PKPD group and develop AI-powered QSP models that integrate biology, pharmacology, and data to drive pivotal decisions in drug discovery.

You will work on mechanistic PK/PD modeling, parameter estimation, and cross-functional collaboration, contributing to translational insights and publications. This fixed-duration role offers opportunities for extension and future full-time placement.

Qualifications

PhD in quantitative pharmacology, systems biology, or related field.
Experience in developing QSP/mechanistic PKPD models or ODE-based models for biological systems.
Experience with development of virtual patient populations.
Experience with R, MATLAB/SimBiology, Python, NONMEM, Monolix or related software.
Experience with parameter estimation and sensitivity analysis.
Authorized to work in the United States on a full-time basis.

Responsibilities

Consolidate preclinical and clinical data to inform model design.
Design and implement an ODE-based QSP model capturing PK/PD and biology.
Perform parameter estimation, simulations and analyses.
Inform dosing strategies and translational questions with model insights.
Communicate results to cross-functional teams and maintain documentation.
Present findings at scientific conferences and publish in peer-reviewed journals.