Proteome Editor Lead for AI-Driven Design Flywheel

Allen Institute; Seattle (WA); On-site; USD 128,000 - 160,000; Full time

Benefits offered by this job

Relocation assistance

Possible visa sponsorship

Job summary

The Allen Institute seeks a scientist to lead the Proteome Editor flywheel. This role focuses on cell‑based library screening and functional genomics to design de novo proteome editors that work out of the box.

You will partner with machine learning colleagues to optimize active‑learning strategies, improve turnaround time, and deliver model‑ready datasets while mentoring a high‑performing team onsite in Seattle.

Qualifications

• PhD or equivalent in biochemistry, molecular biology, or related field.
• Minimum 5 years of post‑doctoral experience.
• Experience with functional genomics, MPRA, and high‑throughput screening.
• Proven ability to lead projects and collaborate cross‑functionally with ML teams.

Responsibilities

• Lead the Proteome Editor flywheel team to design‑test‑learn pipelines.
• Oversee library screening and degrader evaluation experiments.
• Collaborate with ML colleagues to define targets and curate data.
• Improve turnaround time, throughput, and model lift.

Skills

Functional genomics

MPRAs

Multiplexed assays

High-throughput screening

Collaboration with ML teammates

Education

PhD in biochemistry or molecular biology

Tools

CRISPR/Cas9 editing

Golden Gate assembly

Gibson assembly

NGS library prep

Mammalian cell culture

Job description

The Allen Institute seeks a scientist to lead the Proteome Editor flywheel. This role focuses on cell‑based library screening and functional genomics to design de novo proteome editors that work out of the box.

You will partner with machine learning colleagues to optimize active‑learning strategies, improve turnaround time, and deliver model‑ready datasets while mentoring a high‑performing team onsite in Seattle.