Computational Protein Designer — ML & Generative AI

AeroVironment, Inc.; Bath Township (OH); On-site; USD 150,000 - 180,000; Full time

Benefits offered by this job

Medical, dental, vision

401K with company matching

9/80 work schedule

Paid holiday shutdown

Job summary

AeroVironment, Inc. seeks a Computational Protein Engineer to lead de novo protein design and optimization for metal separation technologies. The role focuses on machine learning, generative design, and high-throughput in-silico workflows, with collaboration across experimental and computational teams.

You will implement design pipelines on high-performance computers, using Rosetta, RFDiffusion, and LigandMPNN to engineer protein scaffolds and binding pockets for polyvalent metals. U.S.

Qualifications

• PhD in Computational Chemistry, Biophysics, Protein Engineering or related field.
• Strong experience with regression/optimization or transformer models for large datasets.
• Proficiency in Python and/or C++/Rust for pipelines and automation.

Responsibilities

• Lead design and optimization of proteins for metal separation technologies.
• Apply generative AI and machine learning to design novel binding pockets.
• Develop high-throughput in-silico workflows for protein evaluation.
• Collaborate with experimental team to translate predictions into designs.

Skills

Machine learning

Protein design

Python

High performance computing

Data analysis

Education

PhD in Computational Chemistry/Biophysics/Protein Engineering

MS with 5+ years specialized experience

Tools

Rosetta

RFDiffusion

LigandMPNN

Job description

AeroVironment, Inc. seeks a Computational Protein Engineer to lead de novo protein design and optimization for metal separation technologies. The role focuses on machine learning, generative design, and high-throughput in-silico workflows, with collaboration across experimental and computational teams.

You will implement design pipelines on high-performance computers, using Rosetta, RFDiffusion, and LigandMPNN to engineer protein scaffolds and binding pockets for polyvalent metals. U.S.