Proteome Editor Lead - AI-Driven Design & Screening

ClearCompany Talent Management Software; Seattle (WA); On-site; USD 128,000 - 160,000; Full time

Benefits offered by this job

Relocation assistance

Visa sponsorship

Job summary

Allen Institute in Seattle seeks a Scientist III to lead the Proteome Editor design flywheel, guiding a cross‑functional team with ML partners to optimize active learning and model improvements.

You will oversee library screening, degrader evaluations, and data curation to deliver model‑ready datasets and rapid turn‑around. The role emphasizes collaboration, leadership, and communication across research teams.

Qualifications

• PhD in biochemistry, molecular biology, or related field, or equivalent combination of degree and experience.
• Minimum 5 years of relevant post‑doctoral experience.
• Experience with functional genomics, massively parallel reporter assays, multiplexed assays of variant effect, saturation mutagenesis, or plasmid library‑based screening.
• Experience architecting cellular library screening workflows (e.g., MPRAs or other high‑throughput cell‑based discovery platforms).
• Proven ability to lead scientific projects and collaborate cross‑functionally, including partnering effectively with computational/ML teammates.

Responsibilities

• Lead the Proteome Editor team to build and run a rapid, repeatable design–test–learn pipeline focused on proteome editor screening.
• Design and oversee library screening and degrader evaluation experiments to generate high‑quality, model‑ready datasets.
• Partner with machine learning colleagues to define next targets, curate data, and implement active‑learning strategies that choose the next best experiments.
• Optimize flywheel performance by improving turnaround time, throughput, cost, and per‑cycle model lift; identify and remove experimental bottlenecks.
• Coordinate closely with other flywheel leads and AI Biodesign stakeholders to align priorities, timelines, and dependencies across the broader program.
• Mentor and manage a high‑performing team, fostering a collaborative culture and clear communication grounded in strong emotional intelligence.
• Present scientific results and complex concepts internally in talks and progress reports.
• Present results to the external community at conferences and in publications.

Skills

Cell-based screening

Functional genomics

ML collaboration

Project leadership

Education

PhD in Biochemistry / Molecular Biology

Tools

MPRAs

CRISPR/Cas9

NGS

Job description

Allen Institute in Seattle seeks a Scientist III to lead the Proteome Editor design flywheel, guiding a cross‑functional team with ML partners to optimize active learning and model improvements.

You will oversee library screening, degrader evaluations, and data curation to deliver model‑ready datasets and rapid turn‑around. The role emphasizes collaboration, leadership, and communication across research teams.