Protein Scientist, Biomolecular Discovery (I/II)

Magnet Biomedicine, Inc.

Boston (MA)

In loco

USD 115.000 - 155.000

Tempo pieno

14 giorni+

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Descrizione del lavoro

Magnet Biomedicine, Inc. in Boston is seeking a Scientist I/II to join our Biomolecular Discovery team. This role focuses on producing high-quality protein reagents for biochemical assays and generating structural insights to advance small molecule therapeutics.

You will work across cell biology, chemistry, and proteomics in a collaborative environment, employing protein expression, purification, and analytical techniques to support drug discovery from bench to data-driven conclusions.

Competenze

PhD or BS/MS in structural biology, biophysics, biochemistry or related field with 0–5 years (PhD) or 4–10 years (BS/MS) of industrial drug discovery experience.
Hands-on recombinant protein construct design, expression and purification.
Highly organized with strong problem-solving and critical thinking skills.
Effective communication skills with the ability to work independently and collaboratively.

Mansioni

Protein Expression: design plasmid constructs and optimize recombinant protein expression in bacterial, insect, or mammalian systems.
Protein Purification: multi-step purification using affinity, ion-exchange, hydrophobic interaction and size-exclusion chromatography.
Biochemical Characterization: assess protein purity, stability and integrity using SDS-PAGE, Western blot, UV/Vis and fluorescence assays.
Biochemical profiling: evaluate perturbation of protein interactions using FP, TR-FRET and luminescence.
X-ray Crystallography: support data collection and communicate structural insights with collaborators.
Documentation & maintenance: maintain ELNs, calibrate equipment, prepare reports.