Scientist I/II, Biomolecular Discovery

Magnet Biomedicine; Boston (MA); On-site; USD 115,000 - 155,000; Full time

Job summary

Magnet Biomedicine, Inc. in Boston is seeking a Scientist I/II to join our Biomolecular Discovery team. This role focuses on producing high-quality protein reagents for biochemical assays and generating structural insights to advance small molecule therapeutics.

You will work across cell biology, chemistry, and proteomics in a collaborative environment, employing protein expression, purification, and analytical techniques to support drug discovery from bench to data-driven conclusions.

Qualifications

• PhD or BS/MS in structural biology, biophysics, biochemistry or related field with 0–5 years (PhD) or 4–10 years (BS/MS) of industrial drug discovery experience.
• Hands-on recombinant protein construct design, expression and purification.
• Highly organized with strong problem-solving and critical thinking skills.
• Effective communication skills with the ability to work independently and collaboratively.

Responsibilities

• Protein Expression: design plasmid constructs and optimize recombinant protein expression in bacterial, insect, or mammalian systems.
• Protein Purification: multi-step purification using affinity, ion-exchange, hydrophobic interaction and size-exclusion chromatography.
• Biochemical Characterization: assess protein purity, stability and integrity using SDS-PAGE, Western blot, UV/Vis and fluorescence assays.
• Biochemical profiling: evaluate perturbation of protein interactions using FP, TR-FRET and luminescence.
• X-ray Crystallography: support data collection and communicate structural insights with collaborators.
• Documentation & maintenance: maintain ELNs, calibrate equipment, prepare reports.

Skills

Protein expression

Protein purification

Biochemical characterization

Cross-functional collaboration

Documentation & ELN

Analytical thinking

Education

PhD in structural biology/biophysics/biochemistry

BS/MS in structural biology/biophysics/biochemistry

Tools

Affinity chromatography

Ion-exchange chromatography

Size-exclusion chromatography

SDS-PAGE

Western blot

FP / TR-FRET

Job description

About Magnet Biomedicine

Magnet is a biotechnology company pioneering the discovery of oral molecular glues - small molecules that induce proximity between proteins to modulate their function. Our proprietary TrueGlue(TM) platform is designed to address hard-to-drug targets across cancer and immune-mediated diseases.

With support from ARCH Venture Partners, Newpath Partners, Taiho Ventures, and Eli Lilly, Magnet is advancing internal programs in oncology, immunology, and inflammation. Magnet has also entered into a collaboration and license agreement with Eli Lilly to discover, develop, and commercialize specific molecular glue therapeutics in oncology.

Position Summary

We are seeking a Scientist I/II to join our Biomolecular Discovery team. This role offers an opportunity to directly impact Magnet’s drug discovery efforts through production of high-quality protein reagents suitable for biochemical assays and generation of structural insights. This position will work closely with colleagues across cell biology, chemistry, and proteomics, participating in a highly dynamic collaborative environment where cross-functional teamwork drives progress. If you are a curious scientist dedicated to developing novel small molecule therapeutics for patients in need, we encourage you to consider joining our team at Magnet.

Key Responsibilities

• Protein Expression: Design plasmid constructs and optimize recombinant protein expression in bacterial (coli), insect, or mammalian cell systems
• Protein Purification: Execute multi-step protein purification using affinity, ion-exchange, hydrophobic interaction and size-exclusion chromatography
• Biochemical Characterization: Analyze protein purity, stability and integrity using SDS-PAGE, Western blotting, UV/Vis spectroscopy and fluorescence-based assays
• Biochemical compound profiling: Assess compound perturbation of protein-protein interactions utilizing techniques such as FP, TR-FRET and luminescence
• X-ray Crystallography: Support data collection, analysis and communicate structural insights with collaborators
• Documentation & maintenance: Maintain detailed electronic laboratory notebooks (ELN), calibrate equipment, and prepare comprehensive reports

Required Qualifications and Skills

• PhD or BS/MS in structural biology, biophysics, biochemistry or related field with 0-5 years (PhD) or 4-10 years (BS/MS) of industrial drug discovery experience
• Hands-on laboratory experience in recombinant protein construct design, expression and purification
• Highly organized with strong problem-solving and critical thinking skills
• Effective communication skills with the ability to work both independently and collaboratively to progress team objectives

Preferred Qualifications

• Experience with structural biology methods such as X-ray crystallography, cryo-EM, native MS, or HDxMS is preferred
• Experience in proximity induced small molecule drug discovery is preferred

National salary range. Salary will be determined by many factors, including but not limited to, specific competencies, relevant education, qualifications, certifications, experience, skills, performance, location and business or organizational needs.

$115,000—$155,000 USD