Protein Engineer: Antibody Design & Yeast Display

Planet Pharma; Boston (MA); On-site; USD 120,000 - 190,000; Full time

Job summary

Planet Pharma seeks a Protein Engineer with deep expertise in computational design and in vitro display-based discovery to advance next-generation ADC therapeutics. Focus areas include structure-based design, sequence optimization, and conjugation-site selection within antibody architectures, paired with hands-on yeast display platforms.

You will apply rational design methods, lead library construction and selection campaigns, and contribute to biophysical characterization using SPR/BLI and

Qualifications

• Apply rational and computational protein design methods (e.g., structure-based design, sequence optimization) to engineer next-generation ADC therapeutics, from antibody architecture through conjugation site selection.
• Required: Advanced degree in Protein Engineering or related and 2+ years industry experience
• Demonstrated computational protein design experience
• Hands-on experience with yeast display — library construction, selection campaigns, and FACS-based sorting
• Familiarity with biophysical and functional characterization (SPR/BLI, epitope binning)

Responsibilities

• Engineer next-generation ADC therapeutics from antibody architecture through conjugation-site selection.
• Apply rational and computational design methods to optimize sequences and structures.
• Lead yeast display library construction and selection campaigns; perform FACS-based sorting.
• Characterize biophysical and functional properties (SPR/BLI, epitope binning).

Skills

Computational protein design

Yeast display

FACS-based sorting

Biophysical characterization

Conjugation-site selection

Structure-based design

Education

Advanced degree in Protein Engineering or related

Job description

Planet Pharma seeks a Protein Engineer with deep expertise in computational design and in vitro display-based discovery to advance next-generation ADC therapeutics. Focus areas include structure-based design, sequence optimization, and conjugation-site selection within antibody architectures, paired with hands-on yeast display platforms.

You will apply rational design methods, lead library construction and selection campaigns, and contribute to biophysical characterization using SPR/BLI and