Protein Engineer: Phage Display & High-Throughput Discovery (Equity)

Profluent Bio; Emeryville (CA); On-site; USD 132,000 - 167,000; Full time

Benefits offered by this job

Competitive compensation with equity

401(k) with strong match

Health/dental/vision insurance

Generous PTO

Professional development

Job summary

Profluent Bio in Emeryville, CA, is seeking an experienced protein engineer to lead display campaigns and build high-throughput platforms for measuring protein-protein interactions at scale.

This bench-focused role runs campaigns, builds and validates assays, and sets QC controls, collaborating with ML, protein design, automation, and bioinformatics colleagues.

You'll drive end-to-end phage display work, from library construction to hit validation, shaping data for model training and evaluation.

Qualifications

• MS or PhD in a relevant biology field with industry experience.
• Hands-on phage display and antibody discovery experience.
• Strong molecular biology skills for library construction.
• Experience turning sequencing data into quantitative measurements.
• Excellent analytical and troubleshooting skills with meticulous record-keeping.

Responsibilities

• Build founding high-throughput platforms for identifying and measuring protein-protein interactions.
• Lead phage display campaigns end-to-end from library construction through panning, NGS, and hit validation.
• Design and troubleshoot selection strategies, including antigen selection, library QC, and stringency selections.
• Plan campaigns with ML and protein design scientists and define data fit for model training and evaluation.

Skills

Phage display

Antibody discovery

Molecular biology

Data analysis

Education

MS/PhD in Molecular Biology, Biochemistry, Protein Engineering, Biophysics, Immunology

Tools

NGS data analysis

LIMS

Job description

Profluent Bio in Emeryville, CA, is seeking an experienced protein engineer to lead display campaigns and build high-throughput platforms for measuring protein-protein interactions at scale.

This bench-focused role runs campaigns, builds and validates assays, and sets QC controls, collaborating with ML, protein design, automation, and bioinformatics colleagues.

You'll drive end-to-end phage display work, from library construction to hit validation, shaping data for model training and evaluation.