Lead Scientist, Antibody Discovery & Yeast Display

Moderna; Cambridge (MA); On-site; USD 150,000 - 230,000; Full time

Job summary

Moderna is seeking a Senior Scientist for the Antibody Discovery team within Therapeutics Research in Cambridge. You will contribute to antibody discovery, engineering, and optimization with a focus on yeast display and library design to enable lead nomination.

The role involves collaboration with computational and structural biology teams to translate designs into experimentally testable molecules while advancing diverse therapeutic formats.

Qualifications

• PhD with 2+ years industry postdoc/experience in antibody discovery or biologics.
• Hands-on yeast display and library design experience.
• Strong understanding of antibody/protein engineering and developability.
• Collaborative, cross-functional teamwork experience.

Responsibilities

• Lead experimental protein/antibody engineering workstreams from design to lead identification.
• Design and execute yeast surface display workflows and selections.
• Translate designs into testable constructs and guide iterative cycles.
• Collaborate with computational, structural biology, and antigen teams.

Skills

Yeast display

Protein engineering

Antibody engineering

Library design

FACS-based selections

Education

PhD in related field

Tools

NGS analysis

Cloning

Sequence analysis

Job description

Moderna is seeking a Senior Scientist for the Antibody Discovery team within Therapeutics Research in Cambridge. You will contribute to antibody discovery, engineering, and optimization with a focus on yeast display and library design to enable lead nomination.

The role involves collaboration with computational and structural biology teams to translate designs into experimentally testable molecules while advancing diverse therapeutic formats.