Senior Scientist: Antibody Discovery & Yeast Display

Moderna Therapeutics; Cambridge (MA); On-site; USD 131,000 - 209,000; Full time

Job summary

Moderna Therapeutics seeks a Senior Scientist for the Antibody Discovery team in Therapeutics Research. The role focuses on hands-on protein/antibody engineering with emphasis on yeast display, library design, and lead identification across oncology and autoimmune programs.

The candidate will collaborate with design, computational biology, and antigen design teams to translate designs into testable molecules, driving iterative design-build-test-learn cycles in a fast-paced environment.

Qualifications

• PhD in protein engineering, molecular biology, biochemistry, immunology, cancer biology, or related field.
• 2+ years of post-PhD industry experience in antibody discovery or biologics discovery.

Responsibilities

• Design, build, and execute yeast surface display workflows for antibody discovery and engineering.
• Lead experimental workstreams from library design through lead identification and characterization.
• Collaborate with computational design, structural biology, and antigen design teams to translate in silico designs into constructs.
• Characterize candidates using biochemical, biophysical, and functional assays.
• Analyze sequencing data to identify structure–function relationships and guide lead selection.

Skills

yeast display

antibody engineering

molecular biology

library design

experimental characterization

FACS-based selections

data interpretation

Education

PhD in protein engineering/molecular biology/biochemistry/immunology

Tools

Biacore

Carterra

Octet

Flow cytometry

Job description

Moderna Therapeutics seeks a Senior Scientist for the Antibody Discovery team in Therapeutics Research. The role focuses on hands-on protein/antibody engineering with emphasis on yeast display, library design, and lead identification across oncology and autoimmune programs.

The candidate will collaborate with design, computational biology, and antigen design teams to translate designs into testable molecules, driving iterative design-build-test-learn cycles in a fast-paced environment.