Product Manager, Assay E2E

Tempus AI, Inc.; Chicago (IL); Hybrid; USD 85,000 - 130,000; Full time

Benefits offered by this job

Hybrid work model

Incentive compensation

RSUs

Medical benefits

Job summary

Tempus AI, Inc. is seeking a Product Manager to drive assay launches, partnering with operations, R&D, regulatory, and analytics to ensure timely, compliant, high-quality launches.

You will translate complex requirements into clear roadmaps and own end-to-end launch execution from conception through delivery. The role emphasizes cross-functional leadership, backlog prioritization, and continuous improvement of assay infrastructure and tooling, with a strong focus on real-world evidence and

Qualifications

• 3+ years in product management or technical program management in healthcare, diagnostics or life sciences.
• Experience with agile software development and translating requirements into product specs.
• Strong execution mindset to manage multiple cross-functional projects.
• Ability to thrive in fast-paced, ambiguous environments and manage dependencies.
• Comfort working with technical stakeholders and systems-level challenges.
• Excellent written and verbal communication, especially in regulated contexts.
• Highly organized with attention to detail and clarity.
• Experience in launch planning or operational tooling.
• Understanding of genomics and oncology, especially NGS and LDTs is a plus.

Responsibilities

• Launch readiness and execution across systems, workflows, and documentation.
• Translate scientific requirements into structured product plans across teams.
• Collaborate with engineering on backlog, planning, and UAT.
• Develop and maintain a launch playbook with milestones and regulatory checkpoints.

Skills

Product management

Healthcare / Diagnostics

Agile methodologies

Cross-functional leadership

Executive communication

Organization & detail

Launch planning

Stakeholder management

Systems thinking

Tools

Regulatory knowledge

Job description

Passionate about precision medicine and advancing the healthcare industry? Recent advancements in underlying technology have finally made it possible for AI to impact clinical care in a meaningful way. Tempus' proprietary platform connects an entire ecosystem of real-world evidence to deliver real-time, actionable insights to physicians, providing critical information about the right treatments for the right patients, at the right time. Tempus is on a mission to improve patient outcomes through data and technology. The Assay E2E team is critical to this mission — we drive the launch of new assays across a growing portfolio of tests by enabling operational excellence, seamless cross-functional collaboration, and scalable systems. We are seeking a Product Manager to join our team, helping us meet the increasing volume and complexity of assay launches. You’ll partner closely with our internal operations teams — spanning order and sample intake, laboratory, bioinformatics, pathology, variant science and reporting — to build and refine workflows that ensure timely, high-quality launches. This role is ideal for someone who thrives in cross-functional settings, enjoys translating ambiguous requirements into clear roadmaps, and is excited by the opportunity to own mission-critical launches from conception through delivery.

Responsibilities

• Launch Readiness & Execution: Drive the planning and execution that supports assay launches, ensuring readiness across systems, workflows, and documentation. Collaborate with operations, R&D, and regulatory to define requirements, identify bottlenecks, and implement scalable solutions. Support risk mitigation strategies and contingency planning for live or upcoming launches.
• Cross-functional Leadership: Translate technical and scientific requirements into structured, implementable product plans. Serve as the connective tissue across pathologists, regulatory, engineering, customer systems, and reporting teams. Engage with Marketing, Design, and Commercial teams to gather insights that drive customer-centric experiences aligned with the forefront of scientific advancements. Represent product needs in cross-team forums and ensure alignment on dependencies and timelines.
• Product Development & Optimization: Collaborate with engineering on backlog prioritization, iteration planning, and UAT. Support and evangelize system enhancements that improve turnaround time for launching assays, reduce manual work, and enable broader assay capabilities. Leverage learnings from post-launch monitoring to propose and lead improvements to core assay infrastructure and tooling.
• Documentation & Communication: Maintain clear launch plans, decision logs, and requirements documentation. Communicate progress, blockers, and risks to stakeholders proactively and clearly. Champion the end-to-end launch process by further developing our launch playbook that defines cross-functional roles, critical milestones, and regulatory checkpoints for genomic products.

Required Skills & Experience

• 3+ years of product management or technical program management experience (preferably in healthcare, diagnostics, or life sciences).
• Experience working with agile software development teams and translating requirements into product specifications.
• Strong execution mindset with proven ability to manage multiple complex cross-functional projects.
• Ability to thrive in fast-paced, ambiguous environments and manage complex dependencies across multiple disciplines.
• Comfort working with technical stakeholders and systems-level challenges.
• Excellent written and verbal communication skills, especially in high-stakes or regulated contexts.
• Highly organized with strong attention to detail and a bias toward clarity and structure.
• Experience in launch planning or operational tooling.
• Understanding of the genomics and oncology landscape, specifically in Next-Generation Sequencing (NGS) and laboratory-developed tests is a plus.

#LI-Hybrid #LI-HR1 CHI: $85,000-$130,000 NYC/SF: $100,000-$145,000 The expected salary range may vary for other locations. Actual salary may vary based on qualifications and experience.

• Tempus offers a full range of benefits, which may include incentive compensation, restricted stock units, medical and other benefits depending on the position.

We are an equal opportunity employer.

We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Tempus was founded in August of 2015 by Eric Lefkofsky, after his wife was diagnosed with Breast Cancer. Shortly after he founded the company in an effort to bring the power of technology and artificial intelligence to cancer care, he convinced Ryan Fukushima to join as the company’s first employee. Ryan and Eric began assembling a world class team, focused on building the first version of a platform capable of ingesting real time healthcare data in an effort to personalize diagnostics. We built the platform for oncology and have expanded it to neuropsychiatry, cardiology, infectious disease (through COVID), and radiology. Despite our rapid growth, our mission remains the same—to help make sure patients are on the right drug at the right time, so they can live longer and healthier lives. We’re looking for people who can change the world. Who question the status quo and don’t shy away from tough problems. For the builders who are never done building and the learners who are never done learning. We’re looking for passionate people with undying curiosity. Those who want to attack one of the most challenging problems mankind has ever faced. Head on.