Process Engineer - Lilly Medicine Foundry

Eli Lilly and Company; Lebanon (IN); On-site; USD 60,000 - 100,000; Full time

Job summary

An established industry player is seeking a Process Engineer to join their new advanced manufacturing facility in Lebanon, IN. This exciting role involves tackling technical challenges in peptide and oligonucleotide synthesis, ensuring compliance with safety and quality standards, and actively engaging with various teams to optimize processes. The successful candidate will play a pivotal role in the startup of a greenfield manufacturing site, contributing to the development of innovative solutions in drug substance manufacturing. If you are passionate about making a difference in healthcare through engineering, this opportunity is perfect for you.

Qualifications

• 1-4 years of experience in pilot plant or pharmaceutical environments.
• Deep technical interest in Chemical Engineering.

Responsibilities

• Perform risk assessments for peptide and oligo synthesizers.
• Ensure compliance with safety and quality standards.
• Develop and review project plans and timetables.

Skills

Analytical Skills

Problem-Solving Skills

Teamwork

Communication Skills

Creativity

Education

BS in Chemical Engineering

MS in Chemical Engineering

Tools

DeltaV

Dynochem

Aspen

Electronic Lab Notebooks

Job description

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Overview:

At Lilly, we serve an extraordinary purpose. We make a difference for people around the globe by discovering, developing and delivering medicines that help them live longer, healthier, more active lives. Not only do we deliver breakthrough medications, but you also can count on us to develop creative solutions to support communities through philanthropy and volunteerism.

About The Lilly Medicine Foundry:

Lilly recently announced a $4.5 billion investment to create the Lilly Medicine Foundry, a new center for advanced manufacturing and drug development. The first-ever facility of its kind, combining research and manufacturing in a single location, the Medicine Foundry will allow Lilly to further develop innovative solutions to optimize manufacturing processes and increase capacity for clinical trial medicines, while also reducing costs and environmental impact.

*NOTE: final location for this role will be Lebanon, IN site but flexibility to work from Indianapolis will be required throughout 2025 and 2026.

Organizational Overview:

Lilly is currently constructing an advanced research facility for production of API molecules for clinical trials located in Lebanon, IN. This facility is Lilly’s largest investment in a clinical trial manufacturing capacity and is intended to provide APIs for current and future products, including new modalities. This is a unique opportunity to be a part of the startup team for a greenfield manufacturing site, and the successful candidate will help to build the processes and facility to enable a successful startup into GMP manufacturing operations.

Position Summary:

We are seeking a Process Engineer to support the pilot plant facility in Lebanon with a focus on peptide and oligonucleotide synthesis. This position involves solving technical challenges with equipment design, developing and sustaining process knowledge, optimizing processes, and managing equipment capabilities.

Responsibilities:

1. Perform impact and risk assessments for the peptide and oligo synthesizers and unit operations.
2. Learn the lab and plant design for the reactors including automation recipes and procedures.
3. Ensure that people and their environment are safe and that company policies concerning safety are followed.
4. Ensure processing equipment remains compliant with internal Quality System requirements, applicable engineering standards, and cGMP requirements.
5. Assess rig fit by receiving the technical data package for new processes and performing modeling, simulations and/or experimental work as required to ensure heat and mass transfer are acceptable when scaling to the plant.
6. Active engagement and communication with: HSE, Quality Assurance, Tech Services, Development, Operations, FUME/C&Q, Automation, Maintenance, Environmental Monitoring, and Manufacturing.
7. Author, review, or approve high-quality technical reports and regulatory submissions dealing with the work performed by the department. Ensure that records and technical notebooks are adequately maintained.
8. Demonstrate engagement and employ a quality mindset in all endeavors by proactively identifying quality issues and communicating appropriately.
9. Develop or review plans and timetables for project work.

Basic Requirements:

• BS or MS in chemical engineering or related discipline and 1-4 years of experience with a pilot plant, pharmaceutical, biotech, or CMO environment supporting the process engineering of drug substance active pharmaceutical ingredient (API) manufacturing.

Additional Skills/Preferences:

• Deep technical interest and understanding in the field of Chemical Engineering.
• Ability to work well in a team environment incorporating a variety of functional relationships and desire to be point of accountability.
• Experience with any of the following software packages: DeltaV, Dynochem, Aspen, and/or electronic lab notebooks.
• Strong analytical and problem-solving skills.
• Strong oral and written communication skills for a diverse audience, e.g., both operations staff and management.
• Ability to work on own initiative and as part of a Process Team consisting of a diverse group of management, production, science and engineering professionals.
• Understanding of process control systems.
• Creativity to identify improvement opportunities and the tenacity/initiative to see them implemented.
• Guidance/mentoring of others through processes.
• Flexibility to meet business needs.

*Final location for this role is Lebanon, IN but flexibility to work from Indianapolis will be required throughout 2025 and 2026.