Principal Statistical Methodology Scientist: Trial Strategy

Roche; South San Francisco (CA); On-site; USD 185,000 - 344,000; Full time

Benefits offered by this job

Discretionary annual bonus

Job summary

Genentech is seeking a Principal Statistical Methodology Data Scientist to serve as a methodological thought partner, developing and institutionalizing methodologies that improve decision-making at the trial and portfolio levels.

You will collaborate with project teams and biostatisticians, lead education efforts, anticipate regulatory trends, and drive scalable solutions while mentoring junior staff.

Qualifications

• PhD in Biostatistics, Statistics, Data Science, Computer Science, or related quantitative discipline.
• 6+ years of experience designing and applying advanced analytics to complex biomedical data in clinical trial research.
• Deep expertise in statistical computing and advanced modeling with a track record of developing novel analytical solutions.
• Recognized as a technical expert and thought partner within the organization or broader field.
• Experience mentoring others and contributing to internal standards, strategy, or capability development.
• Respect for cultural differences when interacting with colleagues in a global workplace.

Responsibilities

• You serve as a methodological thought partner to study teams, providing expert guidance on complex design and analysis across programs.
• You lead the development and institutionalization of methodologies that improve decision-making at trial and portfolio levels (e.g., quantitative go/no-go criteria, simulation frameworks, model-based projections).
• You shape cross-functional understanding of innovative statistical methods through consultation, publications, and leadership of education efforts.
• You anticipate regulatory trends and industry shifts, integrating relevant methodologies into internal practices and guiding external engagements.
• You act as a connector across teams, surfacing recurring challenges and co-creating scalable solutions to elevate analytical excellence in the organization.
• You drive external collaboration through active participation in consortia, joint working groups, or regulatory-facing initiatives.
• You mentor junior staff and influence the strategic direction of Statistical Methodology through thought leadership, vision-setting, and capability building.

Skills

Statistical computing

Advanced modeling

Mentoring

Education

PhD in Biostatistics, Statistics, Data Science, Computer Science, or related quantitative discipline

Job description

Genentech is seeking a Principal Statistical Methodology Data Scientist to serve as a methodological thought partner, developing and institutionalizing methodologies that improve decision-making at the trial and portfolio levels.

You will collaborate with project teams and biostatisticians, lead education efforts, anticipate regulatory trends, and drive scalable solutions while mentoring junior staff.