Principal Software Architect – Onsite Genomics Platform

Ultipro; Houston (TX); On-site; USD 170,000 - 230,000; Full time

Job summary

Baylor Genetics in Houston is seeking a Principal Software Engineer onsite to lead architecture across our software ecosystem, advancing genetic testing workflows and clinical reporting.

You will mentor engineers, collaborate with geneticists and product leaders, and shape security, scalability, and data integrity across mission-critical systems.

This role requires a BS in CS, 10+ years, expert C#/.NET and React TS, and a track record of delivering robust software in regulated environments.

Qualifications

• BS in Computer Science or related field required.
• 10+ years of professional software engineering experience.
• Expert-level proficiency with C# and .NET.
• Extensive experience architecting React + TypeScript applications and relational databases.
• Proven experience designing, implementing, and governing RESTful APIs and distributed systems.

Responsibilities

• Lead the architecture, design, and development of complex software systems and platforms.
• Define and champion engineering standards, best practices, and long-term technical roadmaps.
• Collaborate with cross-functional teams to translate business needs into scalable, secure, and maintainable solutions.
• Conduct deep technical reviews, guide system design discussions, and ensure architectural consistency across teams.
• Mentor and coach engineers, fostering a culture of technical excellence and continuous learning.
• Drive root-cause analysis and resolution of complex technical issues, ensuring system reliability and data integrity.
• Evaluate emerging technologies and guide strategic adoption where appropriate.
• Partner with product, laboratory, and bioinformatics teams to optimize workflows and enhance operational efficiency.
• Ensure compliance with security, privacy, and regulatory requirements across all software systems.

Skills

C# / .NET

React + TypeScript

Distributed systems design

RESTful APIs

Cloud-native / DevOps

Mentoring engineers

Leadership

Education

B.S. in Computer Science

M.S. preferred

Relevant field degree

Tools

MS SQL Server

PostgreSQL

MySQL

Job description

Baylor Genetics in Houston is seeking a Principal Software Engineer onsite to lead architecture across our software ecosystem, advancing genetic testing workflows and clinical reporting.

You will mentor engineers, collaborate with geneticists and product leaders, and shape security, scalability, and data integrity across mission-critical systems.

This role requires a BS in CS, 10+ years, expert C#/.NET and React TS, and a track record of delivering robust software in regulated environments.