Principal Scientist, Translational Science Program Lead, Immunology

Johnson & Johnson Co.; Cambridge (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Johnson & Johnson is seeking a Principal Scientist, Translational Science Program Lead - Immunology, to own end-to-end translational strategy across discovery through clinical development. This onsite role can be located in Cambridge, MA or Spring House, PA, guiding evidence plans and decisions for portfolio entries and dosing strategies.

The successful candidate will unite deep immunology expertise with biomarker-driven insights, communicating risks and recommendations to project teams and

Qualifications

• Deep immunology expertise and translational judgment.
• Proficiency with multidimensional biomarker data and clinical endpoints.
• Ability to communicate complex evidence and recommendations to cross-functional teams.

Responsibilities

• Own the translational strategy and develop stage-appropriate plans connecting biology, pharmacology and endpoints.
• Anticipate evidence needs and define critical questions, timelines and risks.
• Lead precision medicine strategy for patient stratification and biomarker endpoints; integrate into DPPs and study designs.
• Translate science into clinical plans including dose, regimen, and regulatory strategy.
• Represent Translational Science in matrixed teams across Discovery, Clinical Development and Regulatory.
• Ensure execution readiness by partnering with study leads and laboratory scientists.

Skills

Translational science

Immunology expertise

Biomarkers

Clinical development

Leadership

Job description

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Discovery & Pre-Clinical/Clinical Development

Job Sub Function:

Translational Discovery & Development Biomarkers

Job Category:

Scientific/Technology

All Job Posting Locations:

Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America

Job Description:

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

About Immunology

Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https://www.jnj.com/innovative-medicine

We are searching for the best talent for a Principal Scientist, Translational Science Program Lead - Immunology, for Immunology programs spanning discovery through clinical development. This role is located onsite in either Cambridge, MA or Spring House, PA.

The TSPL will be the scientific and strategic owner of the end-to-end translational strategy for assigned assets, translating therapeutic mechanism and human disease biology into decision-linked evidence plans that guide portfolio entry, dose and regimen selection, proof of biology, patient stratification, clinical development, and regulatory strategy.

The successful candidate will lead through scientific credibility and influence in a highly matrixed environment. They will anticipate upcoming program decisions, integrate expertise across functions, and mobilize teams toward clear recommendations and execution. This role requires deep immunology expertise, strong translational judgment, proficiency with multidimensional biomarker data, and the ability to communicate complex evidence, uncertainty, trade-offs, and recommendations to project teams and governance bodies.

• Own the translational strategy: Develop and maintain integrated, stage-appropriate translational plans that connect disease biology, therapeutic mechanism, pharmacology, biomarkers, clinical endpoints, and key program decisions.
• Anticipate evidence needs: Work one or more inflection points ahead to define critical questions, evidence requirements, decision criteria, timelines, dependencies, risks, and mitigation options.
• Lead precision medicine strategy: Develop testable hypotheses for disease segmentation, patient stratification or selection, response and non-response, and clinically meaningful biomarker endpoints; integrate these hypotheses into target product profiles, study designs, and stage-gate decisions.
• Translate science into clinical plans: Define biomarker strategies addressing target engagement, pharmacodynamic activity, proof of biology, dose and regimen selection, disease heterogeneity, efficacy, safety, and differentiation.
• Lead in the matrix: Represent Translational Science on discovery and clinical development teams and align Discovery, Clinical Development, Translational Medicine, Clinical Pharmacology, Data Science, Biostatistics, Diagnostics, Regulatory, Clinical Operations, Commercial, and other partners around an integrated recommendation.
• Ensure execution readiness: Partner with study leads, laboratory scientists,