Principal Scientist, Translational Science Immunology

CSL Plasma Inc.; Waltham (MA); Hybrid; USD 145,000 - 180,000; Full time

Job summary

CSL Behring in Waltham, MA seeks a Principal Scientist, Translational Science Immunology to lead translational research and preclinical development for Immunology programs. This hybrid role requires three days onsite weekly, with reporting to the Senior Director, Translational Research.

You will design, plan, and execute work-packages in Pharmacology and Translational Research, driving target validation and biomarker strategies while collaborating across research, CROs, and clinical teams.

Qualifications

• PhD required with 10+ years in Immunology or immune-mediated diseases
• Experience translating research into early clinical development
• Ability to design in vitro and ex vivo studies and biomarker strategies

Responsibilities

• Design in vitro and ex vivo studies to investigate mechanism of action and drive target validation
• Develop PD biomarker strategies for non-GLP/GLP toxicology and early clinical studies
• Collaborate with in vivo pharmacology and clinical teams to support indication selection
• Contribute to investigator brochures, regulatory submissions, and clinical study reports
• Align research planning with TA priorities and engage external scientific networks

Skills

Translational science

Preclinical development

Biomarker strategy

Collaborative research

Regulatory submissions knowledge

Education

PhD in Immunology or related field

Job description

CSL Behring is a global biopharmaceutical leader committed to developing innovative therapies for patients with rare and serious diseases. Our Immunology franchise is advancing a diverse pipeline targeting autoimmune and inflammatory conditions across rheumatology, neuroimmunology, and rare dermatology.Could you be our next Principal Scientist, Translational Science Immunology? The job is in our Waltham MA Office. This is a hybrid position three days a week onsite. You will report to the Senior Director, Translational Research.You will be responsible for leading and executing translational research and preclinical development activities in relation to the Research Projects to support the Immunology Therapeutic Area Portfolio. You will focus on design, planning, execution, and reporting of Work-Packages related to Pharmacology and Translational Research. The incumbent fosters innovation and maintains CSL’s scientific leadership. The role includes collaborating with lab staff and CROs, representing the Translational Research team internally and externally, and contributing to strategic initiatives through collaboration, scientific excellence, and project delivery.**RESPONSIBILITIES AND ACCOUNTABILITIES:**1 Design and implement in vitro and ex vivo studies to investigate the mechanism of action of lead therapeutic candidates, understand disease patho-mechanisms and drive target validation activities.2 Design appropriate PD response/biomarker strategies and assays to support non-GLP/GLP toxicology studies and first in human clinical studies/early clinical studies, including writing Biomarker Strategy Documents and leading Biomarker Expert Teams.3 Collaborate with Immunology focused In vivo pharmacology researchers to provide pre-clinical studies in support of indication selection, including writing project proposals, research plans, and research agreements.4 Collaborate with clinical researchers/clinical development team (lead clinicians, clinical pharmacology, clinical biomarkers) to provide pre-clinical studies to support indication selection and biomarker strategy, including writing project proposals, research plans, human ethics applications and research agreements.5 Contribute to writing investigator brochures, regulatory submission, clinical study reports and other documents to support project progression6 Works with Research Therapeutic Area Lead (RTAL) to develop and implement Research Strategy and to ensure project planning and execution is aligned with TA priorities.7 Effectively liaises between Research TA Core team and Translational Research team together with key internal functions regarding strategic priorities and project implementation.8 Provides Research input into early phase NPO due diligence process.9 Works to build external scientific and industry networks relevant to Immunology TA (working with relevant members of Senior Management in Research function)**Experience:*** PhD in discipline relevant to Immunology TA (Immunology, Cellular Biology)* 10+ years academic and / or industry experience relevant to Immunology TA* Immunology or immune-mediated disease(s)Track record in the development and conduct of high-quality research activity relevant to Immunology or immune-mediated disease(s)* Experience in translation of research outcomes into early clinical developmentThe expected base salary range for this position at hiring is $145,000 - $180,000. Please note this salary range reflects the minimum and maximum base pay that CSL expects to pay for this position at the time of this posting in MA. Individual base salary for a successful candidate is determined by qualifications, skill level, experience, competencies and other relevant factors. In addition to base salary, total compensation for this role may also include incentive compensation and equity.