Principal Scientist, Structural Biology — Drug Discovery

Genentech; San Francisco (CA); Presencial; USD 151 000 - 280 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Relocation assistance

Relocation assistance

Resumo da oferta

Genentech in South San Francisco, CA seeks a Principal Scientist in Structural Biology focused on protein dynamics to join its dynamic Structural Biology group. The role emphasizes integrating cryoEM, X-ray crystallography, and computational methods to understand protein dynamics and ligand binding for drug discovery.

You will lead strategy, oversee construct design and structure determination, and mentor teams while driving collaborations across Drug Discovery.

Qualificações

• Ph.D. or equivalent in Biochemistry, Structural Biology, Biophysics, Computational Biology, or related field.
• Minimum of 3 years of relevant post-doctoral experience in industry, academia or a research organization.
• Expert in molecular modeling techniques such as molecular dynamics simulation, structural ensemble modeling, ensemble docking and related techniques.
• Expertise in biomolecular structure determination via cryoEM or X-ray crystallography.
• Proven track record leveraging insights into protein or protein-ligand dynamics to enable, accelerate, and/or improve target identification, pocket discovery, binder discovery, ligand optimization and/or other steps of drug discovery.
• Collaborative leader who guides and motivates teams based on scientific merit and mutual respect.
• Highly organized with strong communication and interpersonal skills.

Responsabilidades

• Lead structural biology strategy and execution within multi-disciplinary drug discovery project teams, offering actionable structural insights.
• Oversee protein construct design, expression, purification, and high-resolution structure determination using cryoEM and/or X-ray crystallography.
• Solve and analyze structures of target protein complexes bound by small molecules, peptides, antibodies or other therapeutic formats.
• Utilize state-of-the-art computational tools alongside experimental data (cryoEM, HDX) to characterize the dynamics of biological macromolecules.
• Translate protein dynamics insights into actionable strategies for target assessment, protein construct and reagent design, hit finding, lead identification, lead optimization or other steps of drug discovery.
• Empower and mentor colleagues in applying computational tools and dynamics/ensemble methods to accelerate drug discovery projects. When appropriate, develop workflows, documentation or training materials.

Conhecimentos

Protein dynamics

CryoEM

X-ray crystallography

Molecular dynamics

Computational biology

Leadership

Formação académica

Ph.D. in Biochemistry/Structural Biology/Biophysics/Computational Biology

Ferramentas

CryoEM data processing software

X-ray data analysis software

Molecular docking software

FEP tooling

Descrição da oferta de emprego

Genentech in South San Francisco, CA seeks a Principal Scientist in Structural Biology focused on protein dynamics to join its dynamic Structural Biology group. The role emphasizes integrating cryoEM, X-ray crystallography, and computational methods to understand protein dynamics and ligand binding for drug discovery.

You will lead strategy, oversee construct design and structure determination, and mentor teams while driving collaborations across Drug Discovery.