Principal Scientist I - Pharmacology

AbbVie Inc.; Chicago (IL); On-site; USD 150,000 - 230,000; Full time

Job summary

AbbVie in North Chicago is seeking a highly motivated scientist to join the Quantitative, Translation & ADME Sciences (QTAS) team. The candidate will lead in vitro ADME projects, drive mechanistic understanding of drug metabolism, and mentor junior scientists in cutting-edge assays and translational modeling.

This role offers opportunities to collaborate with discovery biology, pharmacology and chemistry, publish results, and help translate in vitro findings into the early and late-stage drug

Qualifications

• PhD degree in Biological/Pharmaceutical Sciences/Chemistry or related field with >10 years of ADME pharma/biotech experience; or a Bachelor’s/Master’s with >15 years’ experience in vitro ADME.
• Deep understanding of drug metabolism and ADME including IVIVE and DDI risk assessment.
• Strong publication record and leadership in in vitro ADME.
• Excellent communication and ability to work in cross-functional teams.

Responsibilities

• Evaluate novel in vitro tools to predict human PK and DDI potential.
• Lead, mentor and coach junior staff in in vitro drug metabolism.
• Collaborate with QTAS and other scientists to build translational models.
• Communicate findings on in vitro drug metabolism internally and externally.
• Stay current with literature and publish research findings.

Skills

Enzymology and drug metabolism

In vitro ADME modeling

Team leadership

Scientific communication

DMPK project leadership

Education

PhD in Biological/Pharmaceutical Sciences/Chemistry

Bachelor’s or Master’s with 15+ years in vitro ADME

Tools

IVIVE modeling tools

Publications tracking tools

Job description

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on LinkedIn, Facebook, Instagram, X and YouTube.

Job Description

Key Responsibilities

AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago. The ideal candidate will have a strong background and expertise in drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis, ability to drive cutting-edge science and lead a team of junior scientists. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working in a laboratory and non-laboratory setting, the position will involve the conduct and scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to implement and/or evaluate new technologies and approaches to support the mechanistic and translational understanding of early and late-stage small molecules to facilitate rapid advancement of drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

Core responsibilities include:

• Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential


• Lead, mentor and coach junior staff in established and novel practices in vitro drug metabolism


• Liaise with QTAS, discovery biology/pharmacology/chemistry scientists to generate data and knowledge supporting the build-up of translational, mechanistic models


• Communicate internally and externally on topics related to in vitro drug metabolism


• Keep up to date with emerging literature and science in modeling and in vitro approaches


• Externalize research in the form of full length publications and oral presentations.

Qualifications

Basic Qualifications:

• PhD degree Biological/Pharmaceutical Sciences/Chemistry or related field with >10 years of relevant ADME pharma/biotech industry experience; or a Bachelor’s/Master’s degree with > 15 years’ experience with in vitro ADME experiments and DMPK projects, through academic or industry work.


• Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment


• Strong and relevant publication record as well as a track record of strategic scientific leadership in the in vitro ADME field


• Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor


• Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.

Key Leadership Competencies:

• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance


• Ability to inspire and lead others in areas of your expertise


• Learns fast, grasps the \"essence\" and can change course quickly where indicated


• Raises the bar and is never satisfied with the status quo


• Creates a learning environment, open to suggestions and experimentation for improvement


• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.


• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.


• This job is eligible to participate in our long-term incentive programs.

Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employer remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company's sole and absolute discretion, consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html