Principal Scientist I - Pharmacology

AbbVie Inc.; North Chicago (IL); Presencial; USD 125.000 - 237.000; Jornada completa

Descripción de la vacante

AbbVie Inc. in North Chicago seeks a highly motivated scientist to join the QTAS team, leading in vitro drug metabolism efforts and translational modeling to advance small molecule programs.

The role emphasizes oversight of in vitro assays, collaboration across discovery biology, pharmacology, and chemistry, and publication of findings to drive the global ADME strategy.

Formación

• PhD or equivalent with >10 years ADME pharma/biotech experience; or Bachelor/Master with >15 years in vitro ADME
• Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment
• Strong publication record and leadership in in vitro ADME
• Excellent communication and presentation skills, able to work in teams
• Willingness to lead and mentor junior staff and collaborate cross-functionally
• Interest in translational modeling and adoption of new technologies

Responsabilidades

• Evaluate novel in vitro tools and methods to predict human PK and DDI
• Lead and coach junior staff in in vitro drug metabolism
• Collaborate with discovery biology/pharmacology/chemistry to build translational models
• Communicate research findings internally and externally
• Stay current with literature and emerging modeling approaches
• Publish research and present findings externally

Conocimientos

ADME in vitro

enzyme kinetics

IVIVE

DDI risk assessment

leadership

scientific communication

team mentoring

Educación

PhD in Biological/Pharmaceutical Sciences/Chemistry

Bachelor's/Master's with 15+ years in vitro ADME

Descripción del empleo

• Compensation: USD 124,500 - USD 236,500 - yearly

Company Description

About AbbVie

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including immunology, oncology and neuroscience - and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on LinkedIn, Facebook , Instagram , X and YouTube.

Job Description

Key Responsibilities
AbbVie is seeking a highly motivated and experienced scientist to join our Quantitative, Translation & ADME Sciences (QTAS) team in North Chicago.The ideal candidate will have a strong background and expertise in drug metabolizing enzyme function, drug-drug interaction concepts, quantitative bioanalysis, ability to drive cutting-edge science and lead a team of junior scientists. Applicants having experience in an adjacent area, such as drug permeability and transport, receptor pharmacology and pharmacokinetic modeling is desirable. In this exciting role, you will be expected to participate in implementing innovative and quantitative approaches to advance translational ADME using conventional as well as more complex in vitro models. Working in a laboratory and non-laboratory setting, the position will involve the conduct and scientific leadership of in vitro assays as well as applying translational modeling concepts to help drive the global in vitro ADME strategy at AbbVie. The candidate will be expected to implement and/or evaluate new technologies and approaches to support the mechanistic and translational understanding of early and late-stage small molecules to facilitate rapid advancement of drug candidates in our pipeline. In addition, you will have opportunities to contribute to broader areas within DMPK as your experience and expertise warrants.

Core responsibilities include:

• Evaluating novel in vitro tools and methods, and apply established methods and concepts to enable and improve prediction of human PK and drug-drug interaction potential
• Lead, mentor and coach junior staff in established and novel practices in vitro drug metabolism
• Liaise with QTAS, discovery biology/pharmacology/chemistry scientists to generate data and knowledge supporting the build-up of translational, mechanistic models
• Communicate internally and externally on topics related to in vitro drug metabolism
• Keep up to date with emerging literature and science in modeling and in vitro approaches
• Externalize research in the form of full length publications and oral presentations.

Qualifications

Basic Qualifications:

• PhD degree Biological/Pharmaceutical Sciences/Chemistry or related field with >10 years of relevant ADME pharma/biotech industry experience; or a Bachelor’s/Master’s degree with > 15 years’ experience with in vitro ADME experiments and DMPK projects, through academic or industry work.
• Deep understanding of drug metabolism and ADME principles including enzyme kinetics, IVIVE and DDI risk assessment
• Strong and relevant publication record as well as a track record of strategic scientific leadership in the in vitro ADME field
• Highly motivated, self-driven and results-oriented person with excellent communication and presentation skills, capable to work both as team player and independent scientific contributor
• Passion for generating ideas, learning, solving technical problems and applying new technologies to further scientific goals.
• Builds strong relationships with peers and cross functionally with partners outside of team to enable higher performance
• Ability to inspire and lead others in areas of your expertise
• Learns fast, grasps the "essence" and can change course quickly where indicated
• Raises the bar and is never satisfied with the status quo
• Creates a learning environment, open to suggestions and experimentation for improvement
• Embraces the ideas of others, nurtures innovation and manages innovation to reality

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemayultimatelypaymore or less than the posted range. This range may bemodifiedin thefuture.
• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.
• This job is eligible toparticipatein our long-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employeeremains in the Company's sole andabsolutediscretion unless and until paid andmay bemodifiedat the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

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