Principal Scientist, Engineered CAR T Discovery

Biopharma Careers; Seattle (WA); On-site; USD 152,000 - 185,000; Full time

Benefits offered by this job

Health Coverage

Wellbeing Support

Financial Well-being and Protection

Paid Time Off

Job summary

Bristol Myers Squibb is seeking a Principal Scientist for Engineered Cell Therapy Discovery in Seattle to lead the development of next-generation CAR T and eTCR T cell therapies. The role drives strategy, mentors scientists, and partners with cross-functional teams to advance preclinical programs toward clinical development.

The candidate will design genetic constructs, optimize delivery methods, and translate in vitro findings into in vivo models, shaping drug discovery decisions and

Qualifications

• Bachelor’s Degree required.
• Master’s Degree preferred.
• Ph.D. or equivalent advanced degree in Life Sciences required.
• 4+ years of relevant experience in academic or industry settings.
• Strong leadership of independent research programs preferred.

Responsibilities

• Provides scientific leadership and sets strategic direction for engineered CAR T and eTCR T cell therapy programs.
• Leads in vitro functional screening for T cell cytotoxicity and cytokine production.
• Designs and optimizes genetic constructs and gene delivery approaches to improve potency and safety.
• Mentors junior scientists and guides cross-functional project teams.
• Translates in vitro findings to in vivo xenograft studies to inform go/no-go decisions.
• Collaborates across wet lab, computational, and clinical teams across multiple sites.
• Delivers data-driven research strategy presentations to senior leadership.

Skills

Immunology expertise

Cell therapy

Leadership in research

Cross-functional collaboration

Mentoring

Data interpretation

Education

Bachelor’s Degree

Master’s Degree

Ph.D. in Life Sciences

Tools

Flow cytometry

Cytotoxicity assays

Genetic construct design

Lentiviral vectors

AAV vectors

Gibson Assembly

Golden Gate cloning

Job description

Bristol Myers Squibb is seeking a Principal Scientist for Engineered Cell Therapy Discovery in Seattle to lead the development of next-generation CAR T and eTCR T cell therapies. The role drives strategy, mentors scientists, and partners with cross-functional teams to advance preclinical programs toward clinical development.

The candidate will design genetic constructs, optimize delivery methods, and translate in vitro findings into in vivo models, shaping drug discovery decisions and