Principal Scientist, DMPK & PK/PD Strategy

Merck; West Point (PA); Hybrid; USD 173,000 - 273,000; Full time

Benefits offered by this job

Hybrid work arrangement

Job summary

Merck is seeking a Principal Scientist in the DMPK group at West Point, PA to lead integrated DMPK analyses across modalities, delivering PK/PD insights to support development and discovery of novel therapeutics. The role emphasizes cross-functional collaboration, in silico/in vitro/in vivo analyses, and DDI risk assessment to guide clinical programs.

The candidate will drive program decisions and mentor staff in a fast-paced environment.

Qualifications

• PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biomedical Engineering, Biochemistry, or relevant life sciences fields.
• Demonstrated ability to support early to late stage clinical development programs as a DMPK representative including evaluating and mitigating risks, integrating emerging data into ongoing programs, and clearly communicating with a varied development team.
• Ability to drive DDI strategy for clinical programs, ensuring timely risk assessment and appropriate clinical plans are in place.
• Experience with authoring documents in support of IB, IND, WMA filings, and responses to regulatory inquiries.
• Experience working as a DMPK lead on discovery teams advancing therapeutics to clinical development across modalities (small molecule, peptides, biologics and conjugates).
• Strong leadership, interpersonal, communication, problem solving, and collaboration skills, while delivering results on firm deadlines.

Responsibilities

• Work within cross-functional teams to contribute to clinical development and discovery of therapeutics across modalities.
• Guide design and interpretation of in silico, in vitro, and in vivo analyses to support DMPK
• Assess program risks including DDI, metabolism and translation to guide clinical development teams.
• Author source reports and regulatory documents in support of filings.
• Independently evaluate and predict potential program risks and implement strategies to address liabilities.

Skills

ADME

Bioanalytical Method Development

Biopharmaceuticals

Biopharmaceutics

Business Interactions

Clinical Development

Clinical Judgment

Cross-Functional Teamwork

Detail-Oriented

Drug Development

Drug Interactions

Drug Metabolism

Immunoassays

Innovation

Life Science

Mentoring Staff

Pharmacodynamics

Pharmacokinetics

Pharmacology

PKPD Modeling

Education

PhD or Master’s degree in Pharmaceutical Sciences, Pharmacology, Chemistry, Biomedical Engineering, Biochemistry, or relevant life sciences fields.

Job description

Merck is seeking a Principal Scientist in the DMPK group at West Point, PA to lead integrated DMPK analyses across modalities, delivering PK/PD insights to support development and discovery of novel therapeutics. The role emphasizes cross-functional collaboration, in silico/in vitro/in vivo analyses, and DDI risk assessment to guide clinical programs.

The candidate will drive program decisions and mentor staff in a fast-paced environment.