Principal Scientist, DMPK Strategy & Collaborations

calicolabs; South San Francisco (CA); On-site; USD 197,000 - 235,000; Full time

Job summary

Calico Life Sciences LLC is seeking a Principal Scientist in Drug Metabolism and Pharmacokinetics to lead DMPK strategy within our Drug Discovery team. The role is an individual contributor position, collaborating with external partners such as Pharma and CROs to advance therapeutic programs.

The candidate will design, coordinate, and interpret DMPK studies, providing data-driven insights for candidate selection and regulatory submissions. Onsite work five days a week is expected.

Qualifications

• PhD required in pharmacokinetics or drug metabolism.
• 8+ years of DMPK experience in the pharmaceutical/biotech industry.
• Experience as a DMPK functional representative on drug discovery teams.
• Strong understanding of DMPK principles and their application to drug discovery and development.
• Excellent communication and collaboration skills.

Responsibilities

• Develop and implement the DMPK strategy to support drug discovery and development programs.
• Provide expert DMPK guidance to project teams and external stakeholders.
• Collaborate with CROs and external partners to execute DMPK studies and ensure timely delivery.
• Coordinate design, execution, and interpretation of in vitro and in vivo DMPK studies.
• Author and review DMPK reports and regulatory documents.

Skills

DMPK experience

Cross-functional collaboration

Data analysis

Regulatory awareness

Leadership & strategy

Education

PhD in pharmacokinetics or drug metabolism

Tools

Phoenix WinNonlin

GastroPlus

SimCYP

Job description

Calico Life Sciences LLC is seeking a Principal Scientist in Drug Metabolism and Pharmacokinetics to lead DMPK strategy within our Drug Discovery team. The role is an individual contributor position, collaborating with external partners such as Pharma and CROs to advance therapeutic programs.

The candidate will design, coordinate, and interpret DMPK studies, providing data-driven insights for candidate selection and regulatory submissions. Onsite work five days a week is expected.