Principal Scientist - Device Physics & Translational PK/PD

Merck; New Jersey; On-site; USD 180,000 - 240,000; Full time

Job summary

Merck is seeking a Principal Scientist to lead physics-based modeling and simulation within the Device Product Assessment and Innovation team in Device Development and Technology. The role connects device physics with translational PK/PD insights, guiding specifications and reducing physical testing through first-principles modeling.

You will drive standards for model verification, validation, and uncertainty, collaborate with translational and PK/PD experts, and mentor scientists across

Qualifications

• Advanced physics-based modeling of device mechanics and PK/PD translation.
• Experience with regulatory submissions and quality systems is a plus.
• Ability to mentor scientists in a matrixed organization.
• Strong communication of technical trade-offs to stakeholders.

Responsibilities

• Set cross-program modeling strategy linking device physics with translational PK/PD insights.
• Lead first-principles modeling of formulation mechanics, flow paths, actuation, and tissue interactions.
• Set model development, verification, validation, and uncertainty standards.
• Partner with translational and PK/PD experts to integrate delivery-environment properties with exposure and biology.
• Advance reusable models and data workflows across partner groups; mentor scientists.
• Lead modeling contributions to design controls, validation protocols, and regulatory submissions; represent the function in forums.

Skills

Cross-functional leadership

Mentoring

Uncertainty quantification

Independent judgment

Education

PhD in Engineering

Tools

MATLAB

ABAQUS

ANSYS

COMSOL

Python

C++

Job description

Merck is seeking a Principal Scientist to lead physics-based modeling and simulation within the Device Product Assessment and Innovation team in Device Development and Technology. The role connects device physics with translational PK/PD insights, guiding specifications and reducing physical testing through first-principles modeling.

You will drive standards for model verification, validation, and uncertainty, collaborate with translational and PK/PD experts, and mentor scientists across