Principal Scientist, Device Physics & Translational PK/PD

Merck & Co.; Rahway (NJ); Hybrid; USD 157,000 - 247,000; Full time

Job summary

Merck & Co. in Rahway, NJ is seeking a Principal Scientist to lead physics-based modeling and simulation within the Device Product Assessment and Innovation team. You will connect device physics with translational PK/PD insights, guiding specifications and reducing physical testing across programs.

You will set standards for model verification, validation, and uncertainty, mentor scientists, and collaborate with teams to inform governance decisions and external collaborations.

Qualifications

• Extensive physics-based modeling and simulation experience across engineering problems.
• Device, drug delivery, or combination product experience preferred but not required.
• Advanced simulation and programming skills with reusable workflows.

Responsibilities

• Set cross-program modeling strategy linking device physics with translational PK/PD insights.
• Lead first-principles modeling of formulation mechanics, flow paths, and tissue interactions.
• Set model development, verification, validation, and uncertainty standards; ensure credible results.
• Collaborate with translational and PK/PD experts to integrate delivery properties and biology.
• Advance reusable models, data workflows, and decision science across partner groups; mentor scientists.
• Contribute to design controls, validation protocols, and regulatory submissions with QA/R&D.

Skills

Biomedical Eng

Combination Products

Cross-Functional Comms

Drug Delivery

FEA

Human Factor Eng

Mechanical Eng

Mechanical Testing

Device Quality Systems

Next Gen Sci Standards

Pharmacokinetics

Physics Simulation

Process Development Eng

Risk Management

Simulation Programming

Education

Tools

MATLAB

ABAQUS

ANSYS

COMSOL

Python

C++

Job description

Merck & Co. in Rahway, NJ is seeking a Principal Scientist to lead physics-based modeling and simulation within the Device Product Assessment and Innovation team. You will connect device physics with translational PK/PD insights, guiding specifications and reducing physical testing across programs.

You will set standards for model verification, validation, and uncertainty, mentor scientists, and collaborate with teams to inform governance decisions and external collaborations.