Lead Scientist, Chemical Proximity Drug Discovery

St. Jude Children's Research Hospital, Inc.; Memphis (TN); On-site; USD 138,000 - 262,000; Full time

Benefits offered by this job

Medical & Prescription Drug Plans

Dental Plan

Vision Plan

Retirement Plan

Wellness Program

Time Off Programs

Educational Benefits

Job summary

St. Jude Children's Research Hospital seeks a Principal Scientist to direct our Chemical Induced Proximity Center within the Department of Chemical Biology and Therapeutics.

The role leads a strategic, cross-functional program across small molecule discovery, including PROTACs and molecular glue platforms, with a focus on translational impact for pediatric diseases. You will manage a multidisciplinary team, mentor scientists, collaborate with internal departments and external CROs, and help

Qualifications

• Bachelor's degree in a relevant scientific area is required; PhD preferred.

Responsibilities

• Direct strategic decisions across stages of small molecule drug discovery for chemically induced proximity platforms.
• Lead and manage a multidisciplinary team and external CROs; drive cross-functional collaboration.
• Oversee SAR studies to optimize potency, selectivity, and drug-like properties; advance pharmacokinetic/pharmacodynamic profiles.
• Contribute to publications and patents and participate in in-licensing evaluations.

Education

Bachelor's degree in relevant scientific area

PhD preferred

Job description

St. Jude Children's Research Hospital seeks a Principal Scientist to direct our Chemical Induced Proximity Center within the Department of Chemical Biology and Therapeutics.

The role leads a strategic, cross-functional program across small molecule discovery, including PROTACs and molecular glue platforms, with a focus on translational impact for pediatric diseases. You will manage a multidisciplinary team, mentor scientists, collaborate with internal departments and external CROs, and help