Principal Scientist, AI-Driven Inflammation Discovery

Amgen SA; South San Francisco (CA); On-site; USD 180,000 - 250,000; Full time

Benefits offered by this job

Flexible work models

Job summary

Amgen in South San Francisco, CA seeks a Principal Scientist to advance integrated computational and experimental inflammation discovery. You will combine wet-lab biology with AI/ML-driven approaches to accelerate therapeutic insights and drive translational programs.

In this role, you will design studies, generate high-quality data, and interpret findings across literature, genetics, and clinical observations.

Qualifications

• Experience collaborating in matrixed research environments.
• Ability to balance scientific rigor with urgency and adaptability.
• Commitment to teamwork, knowledge sharing, and continuous improvement.

Responsibilities

• Continuously apply AI-driven approaches to generate mechanistic insights and refine therapeutic hypotheses.
• Design, execute, analyze, and interpret studies to investigate disease mechanisms.
• Generate high-quality experimental data to support target identification and validation.
• Integrate experimental findings with literature, human genetics, and clinical observations.
• Participate in scientific discussions, target reviews, and portfolio evaluations with data-driven insights.
• Present scientific findings and recommendations to project teams and governance forums.
• Maintain accurate documentation and contribute to organizational knowledge-sharing.
• Embrace a culture of scientific curiosity, collaboration, and continuous learning.

Skills

Collaborative work style

Matrixed team experience

Scientific rigor

Adaptability

Teamwork

Education

PhD (or MD/PharmD) in a relevant field

Master’s degree with 5+ years in Inflammation/Immunology

Bachelor’s degree with 7+ years in Inflammation/Immunology

Job description

Amgen in South San Francisco, CA seeks a Principal Scientist to advance integrated computational and experimental inflammation discovery. You will combine wet-lab biology with AI/ML-driven approaches to accelerate therapeutic insights and drive translational programs.

In this role, you will design studies, generate high-quality data, and interpret findings across literature, genetics, and clinical observations.