Principal Research Scientist I, Analytical Chemistry

AbbVie Inc; North Chicago (IL); On-site; USD 80,000 - 120,000; Full time

Job summary

An established industry player is seeking a talented individual to join their Analytical Research & Development team. This role focuses on the innovative characterization of peptide and oligonucleotide biomolecules using advanced analytical techniques, particularly mass spectrometry. The successful candidate will lead the development of cutting-edge methods, collaborate with cross-functional teams, and contribute significantly to the advancement of therapeutic programs. If you have a passion for scientific innovation and a strong background in analytical chemistry, this opportunity offers a rewarding career path with the chance to make a meaningful impact on health solutions.

Benefits

Medical/Dental/Vision Insurance

401(k) Plan

Paid Time Off

Short-term Incentive Programs

Long-term Incentive Programs

Qualifications

• PhD with 6+ years in Analytical Chemistry or Biochemistry required.
• Deep understanding of peptide and oligonucleotide characterization.
• Experience in biomolecule analysis and interpretation by NMR spectroscopy.

Responsibilities

• Lead development of analytical characterization methods for peptides and oligonucleotides.
• Collaborate with project teams to advance programs through development.
• Source emerging scientific trends and integrate them into objectives.

Skills

Mass Spectrometry

Peptide Characterization

Oligonucleotide Characterization

LC Separations

NMR Spectroscopy

Analytical Chemistry

Education

PhD in Analytical Chemistry or related field

Tools

Capillary Electrophoresis

Optical Spectroscopy

Job description

Company Description

AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us atwww.abbvie.com. Follow @abbvie onX,Facebook,Instagram,YouTube,LinkedInandTik Tok.

Job Description

The Analytical Research & Development team is seeking a talented, highly motivated candidate with experience in the characterization of peptide and oligonucleotide biomolecules. The successful candidate will be responsible for designing, developing, and implementing analytical methods for the characterization of peptides/oligonucleotides using advanced analytical techniques, with an emphasis on mass spectrometry-based methods. We are looking for diverse candidates with strong scientific and leadership experience to join the AbbVie Analytical R&D team and can offer exciting and rewarding career opportunities for these candidates. The ideal candidate will have CMC expertise in analytical development for biomolecule therapeutics. The candidate will be responsible for assisting with the development and execution of analytical methods to support CMC and will participate in phase-appropriate characterization of material and products at all stages of the development process, as well as monitoring completion of tasks and projects.

Responsibilities:

• Lead development and implementation of advanced analytical characterization methods to support complex peptide and oligonucleotide development programs.
• Utilize cutting-edge structure elucidation techniques (e.g., high-resolution, tandem mass spectrometry) to characterize a wide range of modalities across AbbVie’s pipeline, including oligonucleotide, peptide, and small molecule APIs, starting materials, intermediates, and impurities.
• Be responsible for leading the structure elucidation aspects of a project while collaborating with cross-functional project teams to advance programs through the development pipeline.
• Advance scientific expertise within function. Proactively advise and share knowledge and expert opinions with subordinates, peers, and senior management. Mentor and train colleagues and assesses current and emerging business challenges enabling functional goal achievement.
• Ensure quality and effectiveness of key results of major project plans through sound design, early risk assessments, and implementation of fallback strategies.
• Source and identify emerging scientific trends in the field of molecular characterization of therapeutics from internal and external sources and assess relevance. Integrate trends into functional short-term objectives. Advance technology and direction within area of discipline.
• Apply imagination and innovation by creating, inventing, and implementing new or better approaches, alternatives and breakthrough ideas.
• Make significant contributions to project team and deliver results in a team-oriented setting and will work across scientific disciplines to drive programs through critical milestones.
• Generate new scientific proposals and lead those efforts. Anticipate and critically evaluate scientific or regulatory advances and respond with appropriate new strategies.

Qualifications

• PhD (with 6+ years’ experience) in scientific discipline (e.g., Analytical Chemistry, Biochemistry, or related field) with previous laboratory experience.
• Deep understanding of peptide and/or oligonucleotide characterization, including higher order structure, chiral identification, and comparability assessments by mass spectrometry and other biophysical techniques (e.g. optical spectroscopy, structure, and binding).
• Experience in biomolecule analysis and interpretation by NMR spectroscopy a plus.
• Practical experience and strong knowledge of LC separations (e.g., IP-RP LC, SEC), capillary electrophoresis, and other separation techniques as applied to peptide/oligonucleotide analysis.
• Must possess a solid understanding of peptide/oligonucleotide chemistry and biochemistry, particularly as related to drug development process and formulation.
• Experiences with the development of peptides and traditional small molecule modalities are plus.
• Proven ability to innovate with a history of new or improved product release.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.

Additional Information

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible to participate in our short-term incentiveprograms.

• This job is eligible to participate in our long-term incentiveprograms

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Company’s sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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https://www.abbvie.com/join-us/reasonable-accommodations.html