Principal Immunology Scientist, Targeted Degradation

C4 Therapeutics, Inc.; Watertown (MA); Vor Ort; USD 180.000 - 198.000; Vollzeit

Zusammenfassung

C4 Therapeutics, Inc. is seeking an innovative Principal Scientist, Biology (Immunology) to advance autoimmune and inflammatory disease programs using our TORPEDO platform.

This lab‑based role leads projects from target identification through IND‑enabling studies, applying deep immunology expertise to uncover how degraders reshape immune pathways. You will collaborate across biology, pharmacology, and chemistry, mentor scientists, manage CROs, and translate mechanistic insights into

Qualifikationen

• Ph.D. in Immunology with substantial research experience and a track record in biotech/drug discovery.
• Experience with primary immune cell assays and mechanism of action studies across cytokine, innate, T-cell, myeloid and inflammatory pathways.
• Proven leadership with mentorship, program leadership, and CRO/vendor management.

Aufgaben

• Lead mechanism-driven immunology programs from target identification through candidate selection.
• Define links among target degradation, pathway modulation, and immune outcomes through hands-on pharmacology studies.
• Apply immune signaling expertise to select systems, stimuli, and mechanistic readouts.
• Mentor scientists and foster scientific rigor and collaboration.
• Integrate biology, pharmacology, and chemistry data to guide programs.

Kenntnisse

Immune cell assays

Translational pharmacology

Program leadership

Biomarker strategy

Publications patents

Ausbildung

Ph.D. in Immunology

Jobbeschreibung

C4 Therapeutics, Inc. is seeking an innovative Principal Scientist, Biology (Immunology) to advance autoimmune and inflammatory disease programs using our TORPEDO platform.

This lab‑based role leads projects from target identification through IND‑enabling studies, applying deep immunology expertise to uncover how degraders reshape immune pathways. You will collaborate across biology, pharmacology, and chemistry, mentor scientists, manage CROs, and translate mechanistic insights into